Spontaneous pneumothorax has been observed in patients with abnormal levels of alphaj-antitrypsin. We report the case of a young woman with a low level of alpha, -antitrypsin who presented with recurrent episodes of spontaneous pneumothorax and who required pleuroscopy, apical lung resection, and pleurodesis.
SharpeIK, AhmadM, BraunW.Familial spontaneous pneumothorax and HLA antigens. Chest1980;78(2):264–268.
4.
ErikssonS.A 30-year perspective on al-antitrypsin deficiency. Chest1996;110(6 Suppl):237S–242S.
5.
MostafaviS, LiebermanJ.Intermediate alphal-antitrypsin deficiency with apical lung bullae and spontaneous pneumothorax: presence of a Z variant in an American Black. Chest1991;99(6):1545–1546.
6.
PawłowiczA, DroszczW.Pulmonary function and alphal-antitryp- sin levels in patients after so-called idiopathic spontaneous pneumo- thorax. Bull Eur Physiopathol Respir1987;23(1):1–4.
7.
BenseL, LewanderR, EklundG, HedenstiernaG, WimanLG. Non- smoking. non-alphal-antitrypsin deficiency-induced emphysema in nonsmokers with healed spontaneous pneumothorax, identified by computed tomography of the lungsChest1993;103(2):433–438.
8.
LaurellCB, ErikssonS.The electrophoretic al-globulin pattern of serum in al- antitrypsin deficiency. Scan J Clin Lab Invest1963; 15(2):132–140.
9.
StollerJK. Clinical features and natural history of severe alphal- antitrypsin deficiency. Roger S Miller Lecture. Chest1997;111 (6 Suppl):123S–128S.
10.
McElvaneyNG, StollerJK, BuistAS, PrakashUBS, et al. Baseline characteristics of enrollees in the National Heart. Lung and Blood In- stitute Registry of al-antitrypsin deficiency. The Alphal-Antitrypsin Deficiency Registry Study Group. Chest1997;111(2):394–403.
11.
StollerJK, SmithP, YangP, SprayJ.Physical and social impact of alphal - antitrypsin deficiency: results of a survey. Cleve Clin J Med. 1994;61(6):461–467.
12.
LarssonC.Natural history and life expectancy in severe alpha 1- antitrypsin deficiency. PiZ. Acta Med Scand1978;204(5):345–351.
13.
GishenP, SaundersAJS, TobinMJ, HutchisonDCS. Alpha 1-anti- trypsin deficiency. the radiological features of pulmonary emphy- sema in subjects of Pi type Z and Pi type SZ: a survey by the British Thoracic AssociationClin Radiol1982;33(4):371–377.
14.
Survival and FEV1 decline in individuals with severe deficiency of al-antitrypsin. The Alphal-Antitrypsin Deficiency Registry Study Group. Am J Respir Crit Care Med1998;158(1):49–59.
15.
al-Antitrypsin deficiency memorandum from a WHO meeting. Bull World Health Organ1997;75(5):397–415.
