Coenzyme Q10 (CoQ10) is a provitamin manufactured by the body. It functions as a coenzyme for mitochondrial enzymes. It has been shown to be deficient in patients with cardiovascular disease, cancer, Acquired Immune Deficiency Syndrome (AIDS), muscular dystrophy, spontaneous abortion, male infertility, and periodontal disease. Studies of CoQ10 show preliminary efficacy in the treatment of cardiovascular disease, but there is not enough evidence to date to support its benefit in cancer, AIDS, muscular dystrophy, spontaneous abortion, male infertility and periodontal disease treatments. Additional research is needed to evaluate its benefits in the treatment of these other conditions.
AllenL.V.Coenzyme Q-10 high strength capsules. US Pharm.1999; 24(5): 96–9.
2.
LangsjoenP.Introduction to Coenzyme Q10.International Coenzyme Q10 Association; Nov 1997.
3.
MarincolaR.Neurobiology and quantified pharmaco EEG of coenzyme Q10. J Orthomolecular Med.1997; 12(2): 87–95.
4.
ChallemJ., Coenzyme Q10: It may just be the miracle vitamin of the 1990s. The Nutrition Reporter. December 4, 1996
5.
SilvermanH., RomanoJ., ElmerG., eds. The Vitamin Book.New York, NY: Bantam Books;1993.
6.
WeberC., JakobsenT.S., MortensenS.A.Antioxidative effect of dietary coenzyme Q10 in human blood plasma. Internat J Vit Nutr Res.1994; 64: 311–5.
7.
FolkersK., OsterborgA., NylanderM.Activities of vitamin Q10 in animal models and a serious deficiency in patients with cancer. Biochem Biophys Res Commu.1997; 234(2): 296–9.
8.
ChopraR., GoldmanR., SinatraS.Relative bioavailability of coenzyme Q10 formulations in human subjects. Int J Vitam Nutr Res.1998; 68(2): 109–13.
9.
FolkersK., BrownR., JudyWv. Survival of cancer patients on therapy with coenzyme Q10. Biochem Biophys Res Commun.1993; 192(1): 241–5.
10.
CraneF.L., HatefiY., LesterR.I.Isolation of a quinone from beef heart mitochondria. Biochimica et Biophys Acta.1957; 25: 220–1.
LittarruG.P., HoL., FolkersK.Deficiency of coenzyme Q10 in human heart disease: Parts I and II. Internat J Vit Nutr Res.1972; 42(2)291,(3)413.
13.
MitchellP.The vital protonmotive role of coenzyme Q. In: FolkersK., LittarruG.P., YamagamiT., eds. Biomedical and Clinical Aspects of Coenzyme Q.Elsevier, Amsterdam: Plenum Press; 1991.
14.
MitchellP.Respiratory chain systems in theory and practice. In: KimC.H.., eds., Advances in Membrane Biochemistry and Bioenergetics.New York: Plenum Press; 1988.
15.
MitchellP.Possible molecular mechanisms of the protonmotive function of cytochrome systems. J Theoret Bio.1976; 62: 327–67.
16.
MitchellP.Kelin's respiratory chain concept and its chemiosmotic consequences. Journal Science.1979; 206: 1148–59.
17.
BliznakovE.G.From sharks to coenzyme Q10. Adv Exp Med Biol.1976; 73: 441–50.
18.
PeppingJ.Alternative therapies: Coenzyme Q10. Am J Health-Syst Pharm.1999; 56(6): 519–21.
19.
LangjoenP., VadhanavikitS., FolkerK.Response of patients in class III and IV of cardiomyopathy to therapy in a blind and crossover trial with coenzyme Q10. Proc Natl Acad Sci.1985; 82:4240–4.
20.
JudyW., HallJ., TothP.Double blinddouble crossover study of coenzyme Q10 in heart failure. In: FolkersK., YamamuraY., eds., Biomedical and Clinical Aspects of Coenzyme Q.Amsterdam, Netherlands: Elsevier Science; 1986.
21.
LangsjoenH., LangsjoenP., WillisR.Usefulness of coenzyme Q10 in clinical cardiology: A long-term study. Mol Aspects Med.1994; 15(suppl): S2165–75.
22.
DigiesiV., CantiniF., BrodeckB.Effect of coenzyme Q10 on essential arterial hypertension. Curr Ther Res.1990; 47: 841–5.
23.
LangsjoenP., WillisR., FolkersK.Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med.1994; 15(suppl): S265–72.
24.
CombsA., ChoeJ., TruongD.Reduction by coenzyme Q10 of the acute toxicity of adriamycin in mice. Research Communications in Chemical Pathology and Pharmacology.1977; 18: 565–8.
25.
FolkersK., HaniokaT., XiaL.J.Coenzyme Q10 increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS related complex. Biochem Biophys Res Commun.1991; 176(2): 786–91.
26.
FolkersK., MoritaM., McReeJ.Jr.The activities of coenzyme Q10 and vitamin B6 for immune responses. Biochem Biophys Res Commun.1993; 193(1): 88–92.
27.
LockwoodK., MoesgaardS., HaniokaT.Apparent partial remission of breast cancer in “high risk” patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10. Mol Aspects Med.1994; 15(suppl): S231–40.
28.
FolkersK., SimonsenR.Two successful double-blind trials with coenzyme Q10 (vitamin Q10) on muscular dystrophies and neurogenic atrophies. Biochem Biophys Acta.1995; 1271(1): 281–6.
29.
NoiaG., LittarruG., De SantisM.Coenzyme Q10 in pregnancy. Fetal Diagn Ther.1996; 11(4): 264–70.
30.
AngelittiA., ColaciccoL., CallaC.Coenzyme Q: Potentially useful index of bioenergetic and oxidative status of spermatozoa. Clin Chem.1995; 41(2): 217–19.
31.
ManciniA., ConteB., De MarinisL.Coenzyme Q10 levels in human seminal fluid: Diagnostic and clinical implications. Mol Aspects Med.1994; 15(suppl): S249–55.
32.
ManciniA.Coenzyme Q10 concentrations in normal and pathological human seminal fluid. J Androl.1994; 15(6): 591–4.
33.
WilkinsonE., ArnoldR., FolkersK.Treatment of periodontal and other soft tissue diseases of the oral cavity with coenzyme Q. In: FolkersK., YamamuraY., eds., Biomedical and Clinical Aspects of Coenzyme Q. Vol. 1. Amsterdam, Netherlands: Elsevier/North-Holland Biomedical; 1977.
34.
Ubidecarenone drug monograph [online monograph].Englewood, CO: Micromedex; 1995 May. Updated 1998 Mar.
35.
LockwoodK., MoesgaardS., FolkersK.Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10. Biochem Biophys Res Commun.1994; 199(3): 1504–8.
36.
MortensenS., LethA., AgnerE.Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med.1997; 18(suppl): S137–44.
37.
AbergF., AppelkvistE., BroijersenA.Gemfibrozil-induced decrease in serum ubiquinone and alpha- and gamma-toco-pherol levels in men with combined hyper-lipidaemia. EurJ Clin Invest.1998; 28: 235–42.
38.
KishiT., WatanabeT., FolkersK.Bioenergetics in clinical medicine XV. Inhibition of coenzyme Q10-enzymes by clinically used adrenergic blockersof B-receptors. Res Commun Chem Pathol Pharmacol.1977; 17(1): 157–64.
39.
DanyszA.Influence of coenzyme Q-10 on the hypotensive effects of enalapril and nitrendipine in spontaneously hypertensive rats. Pol J Pharmacol.1994; 46(5): 457–61.
