Serum Leptin Is Elevated out of Proportion to the Body Mass Index in Adolescent Females with Familial Combined Hyperlipidemia (FCH)

Abstract

Get full access to this article

View all access options for this article.

References

1. Halaas JL , Gajiwala KS , Maffei M , et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995;269:543-546.

2. Pelleymounter MA , Cullen MJ , Baker MB , et al. Effects of obese gene product on body weight regulation in ob/ob mice. Science. 1995;269:540-543.

3. Weigle DS , Bukowski TR , Foster DC , et al. Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest. 1995;96:2065-2070.

4. Maffei M , Halaas J , Ravussin E , et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1995;1:1155-1161.

5. Considine RV , Sinha MK , Heiman ML , et al. Serum immunoreactive leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292-295.

6. Ostlund Jr RE , Klein S , Yang JW , Gingerich R . Relation between plasma leptin concentration and body fat, gender, diet, and metabolic covariates. J Clin Endocrinol Metab. 1996; 81:3909-3913.

7. Considine RV , Considine EL , Williams CJ , et al. The hypothalamic leptin receptor in humans. Identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes. 1996;19-992-994.

8. Kolaczynski JW , Ohannesian JP , Considine RV , et al. Response of leptin to short-term and prolonged overfeeding in humans. J Clin Endocrinol Metab. 1996;81:4162-4165.

9. Caro JF , Sinha MK , Kolaczynskij W , et al. Leptin: the tale of obesity gene. Diabetes. 1996;45:1455-1462.

10.

10. Cortner JA , Coates PM , Liacouras CA , Jarvik GP . Familial combined hyperlipidemia in children. J Pediatr. 1993;123:177-184.

11.

11. Masucci-Magoulas L , Goldberg IJ , Bisgaier CL , et al. A mouse model with features of familial combined hyperlipidemia. Science. 1997;275:391-394.

12.

12. National Cholesterol Education Program . Report of the expert panel on blood cholesterol level in children and adolescents. Pediatrics. 1992;89 (suppl):495-505.

13.

13. Jacobson MS , Lillienfeld DE . The pediatrician's role in atherosclerosis prevention. J Pediatr. 1987;112:836-841.

14.

14. Feldman J , Shenker IR , Etzel RA , et al. Passive smoking alters lipid profiles in adolescent athletes. Pediatrics. 1991; 88:259-264.

15.

15. Copperman N , Schebendach J , Arden M , Jacobson MS . Nutrient quality of fat and cholesterol-modified diets of children with hyperlipidemia. Arch Pediatr Adolesc Med. 1995;149:333-336.

16.

16. Hammer LD , Kraemer HC , Wilson DM , et al. Standardized percentile curves of body mass index for children and adolescents. Am J Dis Child. 1991;145:259-263.

17.

17. Sinha MK , Opentanova I , Ohannesian JP , et al. Evidence of free and bound leptin in human circulation: studies in lean and obese subjects and during short-term fasting. J Clin Invest. 1996;98:1277-1282.