Childhood Vaccinations in Children With Food or Vaccination-Related Allergic Reactions: A Single-Center Experience

Abstract

Background:

Children with allergic reactions are mostly referred to tertiary centers for vaccination, but confirmed vaccination-triggered allergic reactions are uncommon. In this study, childhood vaccination-triggered allergic reactions in children with food and vaccination-related allergies are evaluated.

Methodology:

Retrospective analysis of 923 doses of vaccine administered in our clinic due to food or vaccine-triggered allergic reactions were conducted.

Results:

868 vaccines were measles-mumps-rubella (MMR) vaccine, 20 were measles vaccine containing alpha-lactalbumin and 35 were other childhood vaccines. A total of 576 of MMR vaccines contained alpha-lactalbumin and 292 did not. Vaccinations were administered without any reactions in 98.9% of patients with previous food allergies. One of the reactions was anaphylaxis. About 55 patients were referred because of previous vaccination-related allergic reactions, and 94.5% of them were vaccinated without any reactions. Mild reactions were encountered in 3 (5.5%) patients. No anaphylaxis was observed.

Conclusion:

Patients with a history of food or vaccination allergies have a low rate of allergic reactions in childhood vaccinations.