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Reiter EO , Brown RS , Longcope C. , Beitins IZ Male-limited familial precocious puberty in three generations. N Engl J Med. 1984;311:515-519.

Holland FJ , Kirsh SE , Selby R. Gonadotropin-independent precocious puberty ("Testotoxicosis"): influence of maturational status on response to ketoconazole. J Clin Endocrinol Metab. 1987;64: 328-332.

Holland FJ Treatment of familial gonadotropin-independent precocious puberty with ketoconazole . In: Graves GD , Cutler GB , eds. Sexual Precocity: Etiology, Diagnosis, and Management. New York, NY: Raven Press Ltd.; 1993:207-219.

Shenker A. , Laue L. , Kosugi S. , et al. A constitutively activating mutation ofthe luteinizing hormone receptor in familial male precocious puberty. Nature. 1993;365:652-654.

Kremer H. , Mariman E. , Otten B. , et al. Cosegregation of missense mutations of the luteinizing hormone receptor gene with familial male-limited precocious puberty. Human Molec Genetics. 1993;2:1779-1783.

Yano K. , Hidaka A. , Saji M. , et al. A sporadic case of male-limited precocious puberty has the same constitutively activating point mutation in luteinizing hormone/choriogonadotropin receptor gene as familial cases. J Clin Endocrinol Metab. 1994;79:1818-1823.

Sonino N. The use of ketoconazole as an inhibitor of steroid production. N Engl J Med. 1987;317:812-818.

Holland FJ , Fishman L. , Baily JD , Fazekas Ata. Ketoconazole in the management of precocious puberty not responsive to LHRH-analogue therapy. N Engl J Med. 1985;312:1023-1028.

Corvol P. , Michaud A. , Menard J. , et al. Antiandrogenic effects of spironolactone: mechanisms of action . Endocrinol ogy. 1975;97:52-58.

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Menard RH , Stripp B. , Gillette JR Spironolactone and testicular cytochrome P-450: decreased testosterone formation in several species and changes in hepatic drug metabolism. Endocrinology. 1974;94:1628-1636.

Pescovitz OH , Comite F. , Hench K. , et al. The NIH experience with precocious puberty: diagnostic subgroups and response to short-term luteinizing hormone releasing hormone analogue therapy. J Pediatr. 1986;108:47-54.