Toxicity From Topical Administration of Diphenhydramine in Children

Gilman AG , Goodman LS , Rall TW , et al. Goodman and Gilman's, The pharmacological basis of therapeutics . 7th ed. New York: Macmillan, 1985:1685.

Hestand HE , Teske DW Diphenhydramine hydrochloride intoxication. J Pediatr 1977;90:1017-8.

Nigro SA Toxic psychosis due to diphenhydramine hydrochloride. JAMA 1968;203:139-40.

Judge DJ , Dumars KW Diphenhydramine (benadryl) and tripelennamine (pyribenzamine) intoxication in children. AJDC 1953;85:545-50.

Wyngaarden JB , Seevers MH The toxic effects of antihistaminic drugs . JAMA 1951;145:277-82.

Krenzelok EP , Anderson GM , Mirick M. Massive diphenhydramine overdose resulting in death. Ann Emerg Med 1982;11:212-3.

Aaron FE A case of acute diphenhydramine hydrochloride poisoning. Br Med J 1953;2:24.

Davis JH , Hunt HH Accidental benadryl poisoning: report of a fatal case. J Pediatr 1949;34:358-61.

Schunk JE , Svendsen D. Diphenhydramine toxicity from combined oral and topical use. AJDC 1988; 142:1020-1.

Woodward GA , Baldassano RN Topical diphenhydramine toxicity in a five-year-old with varicella . Pediatr Emerg Care 1988;4:18-20.

Patranella P. Diphenhydramine toxicity due to topical application of Caladryl. Clin Pediatr 1986;25:163.

Tomlinson G. , Helfaer M. , Wiedermann BL Diphenhydramine toxicity mimicking varicella encephalitis. Pediatr Infec Dis J 1987;6:220-1.

Filloux F. Toxic encephalopathy caused by topically applied diphenhydramine. J Pediatr 1986;108:1018-20.

Carruthers SG , Shoeman DW , Hignite CE , et al. Correlation between plasma diphenhydramine level and sedative and antihistamine effects . Clin Pharmacol Ther 1978;23:375-82.

Douglas WW Histamine and 5-hydroxytryptamine (serotonin) and their antagonists . In: Gilman AG , Goodman LS , Rall TW , et al. Goodman and Gilman's, The pharmacological basis of therapeutics. 7th ed. New York: Macmillan 1985:605-38.

Iverson KV , Hackney KU Antihistamines. In: Haddad LM , Winchester JF , eds. Clinical management of poisoning and drug overdose. Philadelphia: WB Saunders, 1983:503-9.

Benitz WE , Tatro DS The pediatric drug handbook. Second ed. Chicago : Year Book Medical Pub., 1981:30-1.

Simons KJ , Watson Wta , Martin TJ , et al. Diphenhydramine: pharmacokinetics and pharmacodynamics in elderly adults, young adults and children. J Clin Pharmacol 1990;30:665-71.

SavchakVI Diphenhydraminepoisoningaftertopicaladministration. Vestnik Dermatologii Vererologii 1982;1:62.

Rutter N. Drug absorption through the skin: a mixed blessing. Arch Dis Child 1987;62:220-1.

Wahlberg JE Percutaneous absorption. Curr Probl Dermatol 1973;5:1-36.

Reynolds JEF , ed. Martindale. The extra pharmacopoeia. 29th ed. London: Pharmaceutical Press, 1989 :453.

Gleason MN , Gosselin RE , Hodge HC , et al. Clinical toxicology of commercial products. 3rd ed. Baltimore: Williams and Wilkins , 1969:56.

Kopleman R. Camphor. In: Haddad LM , Winchester JF , eds. Clinical management of poisoning and drug overdose. Philadelphia: WB Saunders 1983:926-9.

Skoglund RR , Ware LL , Schanberger JE Prolonged seizures due to contact and inhalation exposure to camphor. Clin Pediatr 1977;16:901-2.

Cdc. Chickenpox in the United States, 1972-1977. J Infect Dis 1979 ;140:257-60.

Brunell PA Varicella-zoster infections. In: Feigin RD , Cherry JD , eds. Textbook of pediatric infectious diseases. Second ed. Philadelphia : WB Saunders Co., 1987:1602-7.

DeVivo DC Acute encephalopathies of childhood. In: Rudolph AM , Hoffman JIE , eds. Pediatr 7th ed. Norwalk, CT: Appleton-Century-Crofts, 1982 :1605-13.