The effects of acute viral hepatitis on theophylline clearance and maintenance dose requirements in a 12-year-old boy are described. Significant alterations in theophylline dosage may be required during the acute and recovery phases of viral hepatitis.
Get full access to this article
View all access options for this article.
References
1.
Paifsky KM, Sitar DS, Rangno RE, et al. Theophylline disposition in patients with hepatic cirrhosis , N Engl Med1977;296: 1495-7.
2.
Mangione A., Imhoff TE, Lee RV, et al. Pharmacokinetics of theophylline in hepatic disease. Chest1978;73:616-22.
3.
Staib AH, Schuppan D., Lissner R., et al. Pharmacokinetics and metabolism of theophylline in patients with liver diseases. Int J Clin Pharmacol Ther Toxicol1980;18:500-2.
4.
Sawchuk R.J. , Zaske DEPharmacokinetics of dosing regimens which utilize multiple intravenous infusions. J Pharmacokinet Biopharm1976;4:183-95.