Computerized Tomography and Ultrasonographic Findings in Massive Thymic Hyperplasia

Abstract

Massive thymic hyperplasia in the neonate and young infant can be difficult to diagnose. Differentiation from neoplastic lesions may require thoracotomy for a pathologic specimen. We review a case in a 15-month-old child referred to our institution and discuss the radiographic, ultrasound, and computerized tomographic features of hyperplastic thymic tissue. We review current concepts of the hyperplastic thymus as an anterior mediastinal mass in infancy.

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References

Whittaker LD , Lynn HB Mediastinal tumors and cysts in the pediatric patient. Surg Clin North Am 1973 ;53:893-904.

Pokorny WJ , Sherman JO Mediastinal tumors. In: Holder TM , Ashcroft KW , eds. Pediatric surgery. Philadelphia: WB Saunders, 1980:241-52.

Ellis FH , Kirklin JW , Hodgson JR , et al. Surgical implications of the mediastinal shadow in thoracic roentgenograms of infants and children. Surg Gynecol Obstet 1955;100:532-42.

Tausend MR , Stern WZ Thymic patterns in the newborn. AJR 1965;95:125-30.

Castellanos A. , Pereiras R. , Garcia O. Angiocardiography in huge hypertrophy of the thymus. AJR 197 1; 112:40-9.

Boyd E. Weight of thymus gland in health and disease. Am J Dis Child 1932;43:1162-214.

Katz SM , Chatten J. , Bishop HC , et al. Massive thymic enlargement: report of a case of gross thymic hyperplasia in a child. Am J Clin Pathol 1977 ;68:786-90.

Lack EE Thymic hyperplasia with massive enlargement. J Thoracic Cardiovasc Surg 1981;81:741-91.

O'Shea PA , Boonchain P. , Farnes P. Giant thymic hyperplasia in infancy: immunologic, histologic, and ultrastructural observations. Lab Invest 1978 ;38:391.

10.

Lee Y. , Moallem S. , Clauss RH Massive hyperplastic thymus in a 22 month old infant. Ann Thorac Surg 1979;27: 356-8.

11.

Griffiths SP , Levine OR , Baker DH , et al. Evaluation of an enlarged cardiothymic image in infancy: thymolytic effect of steroid administration . Am J Cardiol 1961;8:311-8.

12.

Barth K. , Schnauffer L. , Kaufman HJ Case report: giant idiopathic thymomegaly. Pediatr Radiol 1976;4:117-9.

13.

Bower RJ , Kiesewetter WB Mediastinal masses in infants and children. Arch Surg 1977;112:1003-9.

14.

Sealy WC , Weaver WL , Young WG Severe airway obstruction in infancy due to the thymus gland. Ann Thorac Surg 1965;4:389-402.

15.

Teplick JG , Nedwich A. , Haskins ME Roentgenographic features of thymolipoma. AJR 1973;117:873-7.

16.

Grosfeld J. , Ballentine Tvn , Lowe D. , et al. Benign and malignant teratomas in children: 84 cases. Surgery 1976 ;80:297-305.

17.

Grosfeld J. , Weinberger M. , Kilman J. , et al. Primary mediastinal neoplasms in infants and children. Ann Thorac Surg 1971;12:179-90.

18.

Zanca P. , Chuang T. , DeAvilla R. , et al. True congenital mediastinal thymic cyst. Pediatr 1965;36:615-9.

19.

Caffey J. , DiLiberti C. Acute atrophy of the thymus induced by adrenocorticosteroids observed roentgenographically in living human infants. AJR 1959;82:530-40.

20.

Stich MH , Ribinstein J. , Friedman AB , et al. Mediastinal lymphosarcoma in an infant. J Pediatr 1953;42:235-8.