A 12-year-old boy was diagnosed as having acute lymphoblastic leukemia (ALL) at the age of 2 years 10 months. Chemotherapy was discontinued after 33 months of continuous remisson of ALL. Isolated testicular relapse occurred 5 years after . cessation of treatment. Isolated testicular infiltration if it occurs, usually does so within one year after discontinuing treatment. Late bone marrow or extramedul lary relapse usually does not occur after four years post therapy. Testicular relapse in this patient occurred five years after completing chemotherapy.
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References
1.
George SL, Aur Rja, Mauer AM, et al: A reappraisal of the results of stopping therapy in childhood leukemia. N Engl J Med300:269, 1979
2.
Baum E., Sather H., Nachman J., et al: Relapse rates following cessation of chemotherapy during complete remission of acute lymphocytic leukemia. Med Pediatr Oncol7:25, 1979
3.
Land V.J., Berry DH, Hersen J., et al: Long-term survival in childhood leukemia: "late relapse". Med Pediatr Oncol7:19, 1979
4.
Kuo T-T., Tschang T-P., Chu J-Y.: Testicular relapse in childhood acute lymphocytic leukemia during bone marrow remission. Cancer38:2604, 1976
5.
Stoffel TJ, Nesbit ME, Levitt SH: Extramedullary involvement of the testes in childhood leukemia. Cancer35:1203, 1975
6.
MedicalResearch Council: Testicular disease in acute lymphocytic leukemia in childhood . Br Med J1:334, 1978
Nesbit ME, Robinson LL, Ortega JA, et al: Testicular relapse in childhood acute lymphoblastic luekemia: association with pretreatment patient characteristics and treatment: a report for Children's Cancer Study Group. Cancer45:2009, 1980
9.
Sullivan MP, Hargovic M.: Extramedullary leukemia. Clinical Pediatric Oncology, Second edition. St. Louis, CV Mosby, 1977, pp 317-397
10.
Ravindranath Y., Lusher J.: Testicular relapse in childhood acute lymphoblastic leukemia. Proc Am Assoc Cancer Res20:374, 1979 (Abstract)
11.
Finklestein JZ, Dyment PG, Hammond GD: Leukemia infiltration of the testes during bone marrow remission. Pediatrics43:1042, 1969
12.
Askin FB, Land VJ, Sullivan MP, et al: Occult testicular leukemia: testicular biopsy at three years continuous complete remission of childhood leukemia: Southwest Oncology Group Study. Cancer47:470, 1981
13.
Editorial: Testicular infiltrates in childhood leukemia: harbour or harbinger?Lancet2:136, 1978
14.
Baum E., Nesbit M.Jr, Tilfors D., et al: Extent of disease in pediatric patient with acute lymphocytic leukemia experiencing and apparent isolate testicular relapse. Proc Am Assoc Cancer Res20:435, 1979 (Abstract)
