We describe three patients with cystic fibrosis (CF) with four episodes of hy poelectrolytemia, two of which were associated with documented metabolic al kalosis. CF should be included in the differential diagnosis of infants and children presenting with hypoelectrolytemia and metabolic alkalosis. Patients with CF are at risk of developing severe hypochloremia in hot weather and during intercurrent illness. An abrupt diminution of oral intake is an important suggestive sign, alerting the physician to look for the development of hypoelectrolytemia.
Get full access to this article
View all access options for this article.
References
1.
Kessler WR, Andersen DHHeat prostration in fibrocystic disease of the pancreas and other conditions . Pediatrics8:648, 1951
2.
diSant'Agnese PA, Darlings RC, Perera GA, et al: Abnormal electrolyte composition of sweat in cystic fibrosis of the pancreas. Pediatrics12:549, 1953
3.
diSant'Agnese PA: Salt depletion in cold weather in infants with cystic fibrosis of the pancreas. JAMA84:2014, 1960
4.
Gottlieb R.: Metabolic alkalosis in cystic fibrosis. J Pediatr79:930, 1971
5.
Beckerman R. , Taussig L.: Hypoelectrolytemia and metabolic alkalosis in infants with cystic fibrosis. Pediatrics63: 580, 1979
6.
Garinie E., Gerry D., Richardo G.: Soybean formula (Neo-Mullsoy) metabolic alkalosis in infancy. J Pediatr95:987, 1979
7.
McCance RA: Medical problems in mineral metabolism, III. Experimental human salt deficiency . Lancet1:823, 1936
8.
Robson AM, Tateishi S., Ingelfinger JR, et al: Renal function in patients with cystic fibrosis. J Pediatr79:42, 1971
9.
Simopoulos AP , Lapez A., Boat TF, et al: The reninangiotensin-aldosterone system in patients with cystic fibrosis of the pancreas. Pediatr Res5:626, 1971