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Abstract

In order to study predictors of fever response in children with radiologic pulmonary infiltrates treated with antibiotics, 156 children with pneumonia were evaluated with slide test C-reactive protein (CRP), white blood cell count (WBC), erythrocyte sedimentation rate (ESR), blood cultures, acute and con valescent viral and mycoplasma titers, and then followed clinically. Both CRP (+) at a serum dilution of 1:50 and WBC ≥ 15,000 were better predictors of rapid resolution of fever while the patient was receiving antibiotics than were ESR ≥ 30 or temperature ≥ 40 C. WBC ≥ 15,000 was nearly as specific but more sensitive than CRP (+) 1:50 for resolution of fever in either 8, 12 or 24 hours. Positive blood or lung bacterial cultures, but not four-fold or greater viral or mycoplasma titer increases, were also associated with rapid resolution of fever. WBC ≥ 15,000 is useful in predicting rapid fever response in children with pneumonia treated with antibiotics.

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References

Teele DW , Pelton SI , Grant Mja , et al: Bacteremia in febrile children under 2 years of age: results of cultures of blood of 600 consecutive febrile children seen in a "walk-in" clinic. J Pediatr 87:227, 1975

McCarthy PL , Jekel J. , Dolan TF : Comparison of acute phase reactants in ambulatory children with fever. Pediatrics 62:716, 1978

Shuttleworth DB Charney E. : Leukocyte count in childhood pneumonia. Am J Dis Child 122:393, 1971

McCarthy PL , Frank AL , Ablow RC , et al.: Value of C-reactive protein test in the differentiation of bacterial and viral pneumonia. J Pediatr 92:454, 1978

McCarthy PL , Spiesel SZ , Stashwick CA , et al: Radiographic findings and etiologic diagnosis in ambulatory childhood pneumonia. Abstracts, San Antonio, Ambulatory Pediatric Association, 1980

McGowan JE , Bratton L. , Klein JO , Finland M. : Bacteremia in febrile children seen in a "walk-in" pediatric clinic. N Engl J Med 288:1309, 1973

McCarthy PL , Jekel J. , Dolan TF : Temperature greater than or equal to 40°C in children less than 24 months of age: a prospective study. Pediatrics 59:663, 1977

Felix NS , Hironori N. , Kagan BM : Serum C-reactive protein in infections during the first six months of life . Pediatrics 37:270, 1966

Saxstad J. , Nilsson LA , Hanson LA : C-reactive protein in serum from infants as determined with immunodiffusion techniques. Acta Pediatr Scand 59:676, 1970

10.

McCarthy PL , Grundy GF , Spiesel SZ , Dolan TF : Bacteremia in children: an outpatient review . Pediatrics 59:861, 1976

11.

Tillet WS , Francis TO : Serological reactions in pneumonia with a non-protein somatic fraction of pneumococcus. J Exp Med 52:561, 1930

Predicting Fever Response of Children with Pneumonia Treated with Antibiotics

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