Fifty-four patients with previously positive tuberculin reactions were fol lowed for tuberculin sensitivity, between the incubation period of natural rubella and the 40th day after the onset of rash. In many instances, tuberculin sensitivity was partially or completely depressed beginning in the incubation period and extending for up to 4 weeks after rash onset. Two of 3 cases of subclinical rubella infection also showed this phenomenon. The highest inci dence of negative reactions was 83 per cent in the first 3 days after rash onset. A few subjects had a larger skin reaction to tuberculin than the baseline reading during the 2 to 5 weeks after rash onset.
Get full access to this article
View all access options for this article.
References
1.
V. Pirquet, C.: Das Verhalten der Kutanen Tuberkulin-reaktion wahrend der Masern. Deutsch. Med. Wschr.34: 1297, 1908 .
2.
Starr, S., and Berkovich, S.: Effects of measles. gamma-giobulin-modified measles and vaccine measles on the tuberculin test. N. Engl. J. Med.270: 386, 1964 .
3.
Starr, S., and Berkovich, S.The depression of tuberculin reactivity during chickenpox, Pediatrics33: 769, 1964.
4.
Sewell, E.M. , O'Hare, D., and Kendic, E.L., Jr.: The tuberculin test. Pediatrics.54: 650, 1974.
5.
American Thoracic Society: Statement by Committee on Diagnostic Skin Testing. The place of tuberculin testing in relation to live virus vaccines. Am. Rev. Respir. Dis.102: 469, 1970.
6.
Welfare Ministry: Tuberculosis Control Law revised in 1974 (in Japanese).
7.
Japan Rubella Vaccine Research Commission: A study for development of rubella vaccine (1), 1971 (in Japanese).
8.
Ueda, K., Nishida, Y., Oshima. K., Yoshikawa, H., Ohashi, K., and Nonaka, S.: Seven-year follow-up study of rubella syndrome in Ryukyu with special reference to persistence of rubella hemagglutination inhibition antibodies. Japan. J. Microbiol.19: 181, 1975.
9.
Brickman, H.F. , Beaudry, P.H., and Marks, M.I.: The timing of tuberculin tests in relation to immunization with live viral vaccines. Pediatrics55: 392, 1975.
10.
Ganguly, R. , Cusmano, C.L., and Waldman, R.H.: Suppression of cell-mediated immunity after infection with attenuated rubella virus. Infect, Immunol.13: 464, 1976.
