Three lots of Lirutrin (measles-mumps-rubella live, attenuated virus vaccine) were evaluated in a double-blind, placebo-controlled clinical study involving 273 children. The vaccine consisted of a combination of Schwarz strain measles, Jeryl Lynn strain mumps, and Cendehill strain rubella vaccine viruses. The frequency of positive clinical findings was essentially the same in susceptible vaccinees, immune vaccinees, and placebo recipi ents ; indicating that the observed symptoms were not caused by the vaccine. Antibody assay of paired serum samples revealed that measles, mumps, and rubella seroconversion rates in triple susceptible vaccinees were excellent, ranging from 96 to 98 per cent with all three lots com bined. Results of this study show that Lirutrin trivalent vaccine is well tolerated and highly effective.
Get full access to this article
View all access options for this article.
References
1.
DuPan, R.M., Huygelen, C., Petermans, J., and Prinzie, A.: Clinical trials with a live, attenuated rubella virus vaccine: Cendehill 51 strain. Am J. Dis. Child.115: 658, 1968.
2.
Hilleman, M.R. , Weibel, R.E., Buynak, E.B., Stokes, J. Jr., and Whitman , J.E., Jr.: Live, attenuated mumps-virus vaccine. 4. Protective efficacy as measured in a field evaluation . N. Engl. J. Med.276: 252, 1967.
3.
—, Buynak, E.B., Weibel, R.E., and Stokes, J., Jr.: Live, attenuated mumps-virus vaccine . N. Engl. J. Med.278: 227, 1968.
4.
Kenny, M.T., Albright, K.L., and Sanderson, R.P.: Microneutranization test for the determination of mumps antibody in Vero cells . Appl. Microbiol.20: 371, 1970.
5.
—, and Schell, K.R.: Assay of measles and mumps virus and antibody in Vero cells. J. Biol. Standardization3: 291, 1975.
6.
Prinzie, A., Huygelen, C., Gold, J., Farguhar, J., and McKee, J.: Experimental live attenuated rubella virus vaccine. Clinical evaluation of "Cendehill" strain. Am. J. Dis. Child.118: 172, 1969 .
7.
Public Health Service Advisory Committee on Immunization Practices: Recommendations. Morbidity and Mortality Weekly Report21(25) Supplement, 1972.
8.
Ramos-Alvarez, M., Miller, B.H., Jackson, J.E., Schwarz, A.J., and Bessudo, L.: Immunization of children with attenuated measles-rubella bivalent vaccine. Am. J. Dis. Child.129: 474, 1975.
9.
Schwarz, A.J.F. : Immunization against measles: development and evaluation of a highly attenuated live measles vaccine. Ann. Pediatr.202: 241, 1964.
10.
—, et al.: Extensive clinical evaluations of a highly attenuated live measles vaccine. JAMA199: 26, 1967.
11.
Weibel, R.E. , Stokes, J. Jr., Buynak, E.B., Whitman, J.E., Jr., and Hilleman , M.R.: Live, attenuated mumps-virus vaccine. 3. Clinical and serologic aspects in a field evaluation . N. Engl. J. Med.276: 245, 1967.
