The authors describe a child whose H. influenzae menin gitis persisted despite relatively high-dose ampicillin ther apy. They raise the question whether longterm morbidity from H. influenzae meningitis may be greater with ampicil lin than with the older chloramphenicol-penicillin treatment. Two experts were asked to discuss this question in the light of this case report. Their comments follow the main paper.
Get full access to this article
View all access options for this article.
References
1.
Mathies, A.W. , Jr. et al.: Experience with ampicillin in bacterial meningitis. Antimicrobial Agents and Chemotherapy5: 610, 1965.
2.
Young, L.M., Haddow, J.E. and Klein, J.O.: Relapse following acute hemophilus influenza meningitis. Pediatrics41: 516, 1968.
3.
Cherry, J.D. and Sheenan, C.P.: Bacteriologic relapse in hemophilus influenzae meningitis. New Eng. J. Med.278: 1001, 1968 .
4.
Sanders, D.Y. and Garbee, H.W.: Failure of response to ampicillin in hemophilus influenzae meningitis. Am. J. Dis. Child.117: 331, 1969 .
5.
Gold, A.J., Lieberman, E. and Wright, H.T.: Bacteriologic relapse during ampicillin treatment of hemophilus influenzae meningitis. J. Pediatr.74: 779, 1969.
6.
Coleman, S.J. , Auld, E.B., Connor , J.D., Rose-man, S.B. and Warren, G.H.: Relapse of hemophilus influenzae type B meningitis. Ibid.74: 781, 1969.
7.
Levine, M.S. et al.: Recrudescence of H. influenzae meningitis after therapy with ampicillin. Clin. Pediatr. 9: 54, 1970.
8.
Greene, H.L. : Failure of ampicillin in meningitis (letter to the editor). Lancet1: 861, 1968.
9.
Thrupp, L.D. et al.: Ampicillin levels in the cerebrospinal fluid during treatment of bacterial meningitis. Antimicrobial Agents and Chemotherapy1965, p. 206.
10.
Fleming, P.C. et al.: Ampicillin in the treatment of bacterial meningitis. Antimicrobial Agents and Chemotherapy1966, p. 47.
11.
Society for Pediatric Research (Abstract). Atlantic City, New Jersey, 1970.
