Among 58 black children with leukemia, seven had sickle cell trait and one was homozygous for Hb-S. Both of these rates are similar to those for the black population of the United States in general. The presence of sickle cell trait did not appear to influence the median age of onset, the median survival time, or the quality of survival in black children with acute leukemia. The single patient with sickle cell ane mia died a sudden, unexpected death with massive intravascular eryth rocytic sickling secondary to viremia while in a leukemic remission.
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References
1.
Herrick, J.D. : Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia. Arch. Intern. Med.6: 517, 1910.
2.
Kato, K. and Cardozo, W.W.: Hodgkin's disease with terminal eosinophilia occurring in a Negro child with sicklemia. J. Pediatr.12: 165, 1938.
3.
Rodriquez, S. , Sanford, L., Bullock , W. and Booker, C.: Hereditary spherocytosis and sickle cell trait in the Negro. Ibid.68: 589, 1966.
4.
Goldin, A.G. , Kelty, K.C. and Beard, M.F.: Sickle cell anemia terminating in acute myeloblastic leukemia. Ann. Intern. Med.39: 920, 1953.
5.
Sankalé, M., Diop, B., Linhard, J., Bao, O., Kane, P. and Diebalt, G.: Association de leucose et de drépanocytose type AS. Bull. Soc, Med. Afr. Noire lque fr. xiii:692, 1968.
6.
Myerson, R.M. , Harrison, E. and Lohmuller, H.W.: Incidence and significance of abnormal hemoglobins. Am. J. Med.26: 543, 1959.
7.
Hernandez, K. and Tokuhata, G.: Epidemiologic study of childhood leukemia in Memphis and Shelby County, 1939-62. Public Health Rep.81: 598, 1966.
8.
Browning, D. and Gross, S.: Epidemiologic studies of acute childhood leukemia. Am. J. Dis Child. 116: 576, 1968 .
9.
Hersh, E.M., Bodey, G.P., Nies, B.A. and Freireich, E.J.: Causes of death in acute leukemia. JAMA193: 105, 1965 .
10.
Wintrobe, M.M. : Clinical Hematology, sixth ed. Philadelphia, Lea and Febiger, 1967 , p. 613.
11.
Walters, T. , Bushore, M. and Pinkel, D.: Identification of black children with acute lymphocytic leukemia as high risk patients. Proc. Am. Assoc. Cancer Res.11: 81, 1970.
