When longterm corticosteroid therapy is found necessary in children during their growth period, their linear growth should be monitored very carefully. If evidence of growth re tardation occurs, then a change to ACTH should be considered.
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References
1.
Eberlein, W.R. , Bongiovanni, A. and Rodriquez, C.S.: Diagnosis and treatment: the complications of steroid treatment. Pediatrics40: 279, 1967.
2.
Seigel, S.C.: Corticosteroids and ACTH in the management of the atopic child. Pediatr. Clin. N. Amer.16: 287, 1969.
3.
Blodgett, F.M. , Burgin, L., Iczoni, D., Gribetz, D. and Talbot, N.D.: Effects of prolonged cortisone therapy on statural growth, skeletal maturation and metabolic status of children. New Engl. J. Med.254: 636, 1956.
4.
Norman, A.P.: Steroid treatment in asthma. Recent Advances in Paediatrics, Gairdner, D., Ed. 1965, p. 294.
5.
Friedman, M. and Strang, L.B.: Effect of longterm corticosteroids and corticotrophin on the growth of children. Lancet2: 568, 1966.
6.
Tanner, J.M. , Whitehouse, R.H. and Takaishi, M.L.: Standards from birth to maturity for height, weight, height velocity and weight velocity: British children, 1965—Part II. Arch. Dis. Child.41: 613, 1966.
7.
Friedman, M. and Strang, L.B.: The effects of corticosteroid and ACTH therapy on growth and on hypothalamic—pituitary—adrenal axis of children. Scand. J. Resp. Dis. Supplement No. 68, pp. 68-69, 1969.
8.
— and Greenwood, F.C.: The effects of prolonged ACTH or corticosteroid therapy in children on growth and pituitary function. Memoirs of the Soc. Endocrin.17: 249, 1968.
9.
—: The effect of corticotrophin on hypothalamic-pituitary-adrenal function of children. Proc. Soc. Med.61: 291, 1968.
10.
Hartog, H., Gaafor, M.A. and Fraser, R.: Effect of corticosteroids on serum growth hormone. Lancet2: 376, 1964.
11.
Morris, H.G. , Jorgensen, J.R. and Jenkins, S.A.: Plasma growth hormone concentration in corticosteroid treated children. J. Clin. Invest.47: 427, 1968.
12.
Farrell, G.L. and Lamus, B.: Steroids in adrenal venous blood of the dog . Proc. Soc. Exp. Biol.84: 89, 1953.
13.
Romanoff, E.G. , Hudson, D. and Pincus, G.: Isolation of hydrocortisone and corticosterone from human adrenal venous blood. J. Clin. Endocrinol.13: 1546, 1953.
14.
Samuels, L.T. and Uchikawa, T.: Biosynthesis of adrenal steroids. In The Adrenal Cortex, Eisenstein, A. B., Ed. Boston, Little, Brown and Company, 1957, p. 61.
15.
Sadeghi-Najad, A. and Senior, B.: Adrenal function, growth and insulin in patients treated with corticoids on alternate days. Pediatrics43: 277, 1969.
16.
Unger, D.L. and Unger, L.: Allergic reaction to ACTH. Dis. Chest40: 359, 1961.
17.
Rosenblum, A.H. and Rosenblum , P.: Anaphylactic reactions to adrenocorticotrophic hormone in children. J. Pediat.64: 387, 1964.
18.
West, H.F.: Acquired resistance to corticotrophin. Ann. Rheumat. Dis.11: 124, 1966.
19.
Mattingly, D.: A simple fluorimetric method for estimation of free 11-hydroxycorticoids in human plasma. J. Clin. Path.15: 374, 1962.
