One difficulty in deciding whether to dis continue treatment when nephrotoxicity from an anti-infective drug is suspected is that proteinuria, cylindruria, hematuria, and azotemia may be due to the infection itself. Hence when signs of renal injury appear the clinician must consider the like lihood of drug toxicity, the availability of alternative therapy, and the possible conse quences of continuing with the particular agent that may be causing nephrotoxicity.
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