A Clinical Study of Girls With Idiopathic Central Precocious Puberty and Psychological Behavior Problems

Abstract

To understand the psychological effects on behavior of girls with idiopathic central precocious puberty (ICPP) and to explore the role of gonadotropin-releasing hormone analog (GnRHa) in the reversal or blocking of the negative psychological effects on behaviors of girls with ICPP. A total of 100 girls with ICPP diagnosed at the Department of Endocrinology of Jiangxi Children’s Hospital were divided into the treatment group and observation group with 50 cases in each group. The control group consisted of 50 healthy girls examined at our hospital during the same period. The Achenbach Child Behavior Check List ([CBCL] for parents) was used to evaluate the psychological effects on behavior of the girls diagnosed with ICPP and the girls in the control group, and the scores of related behavioral factors were calculated. At the same time, the psychological effects on behaviors of the girls with ICPP treated with GnRHa were followed up. (1) There were 100 girls with ICPP and 30 with behavioral problems. There were 50 normal healthy girls (control group) with 3 cases of behavior problems. Of the 50 girls with ICPP, after treatment, 8 had behavioral issues. The rate of abnormal psychological effects on behavior in the group of girls with ICPP before treatment was significantly higher than in the control group (P < .01), and after treatment, the rate was lower than before treatment (P < .05). (2) The scores of depression, social withdrawal, poor communication, and school discipline violation in the ICPP group were higher than those in the control group, with a statistical significance (P < .01). (3) After 24 months of GnRHa treatment for girls in the ICPP group, the scores of 4 factors, including depression, social withdrawal, poor communication, and violation of discipline in the Achenbach CBCL, were significantly different before and after treatment (P < .05). (1) Girls with ICPP have low self-esteem, low self-confidence, high incidences of psychological effects on behavior problems, manifested in depression, withdrawal, poor communication, discipline violations, and other aspects; (2) GnRHa treatment can reverse the low self-esteem and low self-confidence of girls with ICPP to varying degrees.

Keywords

idiopathic central precocious puberty girl psychological effects on behavior problems

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References

Qiao

Xie

. Case-control study on behavioral problem of girls with earlier onset of sexual development. Zhong Huo Xin Li Wei Sheng Za Zhi. 2008;22(4):249-252.

Yan

Liang

Minlian

Xiaoping

Luo

. Consensus on diagnosis and treatment of central precocious puberty. Chin J Pediatr. 2015;53(06):412-418.

Ministry of Health of the People’s Republic of China. Guidelines for the treatment of precocious puberty (trial). Zhong Guo Er Tong Bao Jian Za Zhi. 2011;19(4):390.

Brauner

. Paediatric endocrinology: treatment of girls with central precocious puberty. Nat Rev Endocrinol. 2015;11(7):386-387. doi:10.1038/nrendo.2015.65.

Liang

Zhou

, et al. Impact of BMI on gonadorelin-stimulated LH peak in premenarcheal girls with idiopathic central precocious puberty. Obesity (Silver Spring). 2015;23(3):637-643. doi:10.1002/oby.21010.

Zheng

Zhu

. Changes in psychological effects on behavior before and after GnRHa treatment in girls with idiopathic central precocious puberty. Zhe Jiang Da Xue Xue Bao. 2008;37(3):289-293.

Leka-Emiri

Chrousos

Kanaka-Gantenbein

. The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP). J Endocrinol Invest. 2017;40(8):789-802. doi:10.1007/s40618-017-0627-9.

Gunnar

Morison

Chisholm

Schuder

. Salivary cortisol levels in children adopted from romanian orphanages. Dev Psychopathol. 2001;13(3):611-628. doi:10.1017/s095457940100311x.

Hines

Whittier

. The clinical evaluation and treatment of female precocious puberty. Prim Care Update Ob/Gyns. 2003;10(1):44-50.

10.

Mercader-Yus

Neipp-López

Gómez-Méndez

, et al. Anxiety, self-esteem and body image in girls with precocious puberty. Rev Colomb Psiquiatr (Engl Ed). 2018;47(4):229-236. doi:10.1016/j.rcp.2017.05.013.

11.

Nacinovich

Buzi

Oggiano

, et al. Body experiences and psychopathology in idiopathic central precocious and early puberty. Minerva Pediatr. 2016;68(1):11-18.

12.

Anselmi

Barros

Teodoro

, et al. Continuity of behavioral and emotional problems from pre-school years to pre-adolescence in a developing country. J Child Psychol Psychiatry. 2008;49(5):499-507. doi:10.1111/j.1469-7610.2007.01865.x.

13.

Chen

. Serum dehydroepiandrosterone sulfate in healthy girls and girls with idiopathic central precocious puberty. Zhong Hua Nei Fen Mi Dai Xie Za Zhi. 2009;25(5):528-529.

14.

Zheng

Zhu

Jiang

. [Psychological effects on behavior of girls with idiopathic central precocious puberty before and after treatment with gonadotropin-releasing hormone analogue]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008;37(3):289-294.

15.

Mul

Oostdijk

Drop

. Early puberty in adopted children. Horm Res. 2002;57(1-2):1-9. doi:10.1159/000057939.

16.

Baumann

Landolt

Wetterwald

Dubuis

Sizonenko

Werder

. Psychological evaluation of young women after medical treatment for central precocious puberty. Horm Res. 2001;56(1-2):45-50. doi:10.1159/000057939.