Increasing Incidence of Community-Associated Atypical Clostridium difficile Disease in Children

Abstract

Forty-one children with a variety of gastrointestinal complaints were diagnosed with Clostridium difficile infections as part of a routine screen over 3 years. The infection had not been suspected prior to the screen. Each child responded to treatment with metronidazole with resolution of their symptoms. These data suggest that community-associated C difficile is increasing and may produce atypical disease and lead to misdiagnosis.

Keywords

Clostridium difficile diarrhea community-acquired infection

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References

Wilson ME Clostridium difficile and childhood diarrhea: cause, consequence, or confounder . Clin Infect Dis. 2006;43:814-816.

Bryant K. , McDonald LC Clostridium difficile infections in children. Pediatr Infect Dis J. 2009;28:1-2.

Kelly CP , LaMont JT Clostridium difficile-more difficult than ever. N Engl J Med . 2008;359:1932-1940.

Dial S. , Delaney JAC , Barkun AN , Suissa S. Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease. JAMA. 2005;294:2989-2995.

Morinville V. , McDonald J.

Clostridium difficile-associated diarrhea in 200

Canadian children. Can J Gastroenterol. 2005;19:497-501.

Vernacchio L. , Vezina RM , Mitchell AA , Lesko SM , Plaut AG , Acheson DW Diarrhea in American infants and young children in the community setting: incidence, clinical presentation and microbiology . Pediatr Infect Dis J. 2006;25:2-7.

Kim J. , Smathers SA , Prasad P. , Leckerman KH , Coffin S. , Zaoutis T. Epidemiological features of Clostridium difficile-associated disease among inpatients at children’s hospitals in the United States, 2001-2006 . Pediatrics. 2008;122: 1266-1270.

Zilberberg MD , Shorr AF , Kollef MH Increase in Clostridium difficile-related hospitalizations among infants in the United States, 2000-2005 . Pediatr Infect Dis J. 2008; 27:1111-1112.

Centers for Disease Control and Prevention. Severe Clostridium difficile-associated disease in populations previously at low risk-four states, 2005. MMWR Morb Mortal Wkly Rep. 2005;54:1201-1205.

10.

Centers for Disease Control and Prevention. Surveillance for community-associated Clostridium difficile- Connecticut, 2006. MMWR Morb Mortal Wkly Rep. 2008; 57:340-348.