Chronic granulomatous disease presenting as invasive pulmonary aspergillosis in an infant is described in this report. Symptoms of chronic, intermittent respiratory distress had been previously attributed to gastroesophageal regurgitation and asthma. The isolation of an unusual pathogen even from a nonsterile site, particularly when symptoms persist, should not be considered as a contamination but prompt further investigation to exclude phagocytic or other immune deficiencies.
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