Infantile-Onset Diabetes Mellitus: A 1-Year Follow-up Study

Abstract

This study evaluates the clinical profiles and outcomes of children with infantile-onset diabetes mellitus (IODM) (onset at <1 year). Twelve infants with IODM presenting to our hospital from January 2003 to December 2007 are analyzed. All undergo thorough history, clinical examination, and investigations and are managed as per hospital-approved protocol and periodically followed up. Of 12 infants (3 boys and 9 girls), 9 have a family history of DM. The median age at onset is 2.5 months. Six infants have features suggestive of Wolcott-Rallison syndrome (WRS), 4 infants have type 1 DM, and 1 infant each has Fanconi-Bickel syndrome and maturity-onset diabetes of young. None have pancreatic agenesis or calculi. Human leukocyte antigen (HLA) typing shows DQ3 and DR15 alleles predominating. Two children with WRS died; the rest are being followed up. The incidence of IODM is increasing, with multiple syndromic associations rather than a single perspective.

Keywords

infant diabetes mellitus syndromes insulin

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References

Kumar SS , Premalatha G. , Mohan V. Infantile type 1 diabetes mellitus (onset less than one year of age): a report of eight patients. Int J Diab Dev Ctries. 2002;22(3): 103-106.

von Mühlendahl KE , Herkenhoff H. Long-term course of neonatal diabetes . N Engl J Med. 1995;333(11):704-708.

Metz C. , Cavé; H. , Bertrand AM , et al; NDM French Study Group. Neonatal diabetes mellitus: chromosomal analysis in transient and permanent cases. J Pediatr. 2002;141(4): 483-489.

Whiteford ML , Narendra A. , White MP , et al. Paternal uniparental disomy for chromosome 6 causes transient neonatal diabetes. J Med Genet. 1997;34(2):167-168.

Polak M. Neonatal diabetes mellitus: insights for more common forms of diabetes . J Clin Endocrinol Metab. 2007;92(10):3774-3776.

Bappa Raghupathy P. , de Silva V. , Khusaiby SM Permanent neonatal diabetes mellitus: clinical presentation and epidemiology in Oman. Arch Dis Child Fetal Neonatal Ed. 1999; 80(3):F209-F212.

Letha S. , Mammen D. , Valamparampil JJ Permanent neonatal diabetes due to KCNJ11 gene mutation. Indian J Pediatr. 2007;74(10):947-949.

Suresh N. , Ganesh R. , Eswararaja T. , Vasanthi T. , Sankar J. , Sathiasekaran M. Neonatal diabetes mellitus with recurrent hepatitis. Indian J Pediatr. 2006;73(5):451-452.