Serum concentrations of insulin-like growth factor binding protein-1 (IGFBP-1) were measured in men and in non-pregnant and pregnant women. Peak serum IGFBP-1 levels occurred mid-gestation followed by a slight decline towards term. Women with gestational diabetes had higher serum IGFBP-1 concentrations than apparently healthy women at comparable gestation. Following administration of an oral glucose load, serum IGFBP-1 concentrations were decreased within 2 h in men and in pregnant women while IGF-I levels remained constant. These results suggested that IGFBP-1 regulates IGF-I activity in pregnancy in a similar manner to that in the non-pregnant state.
RinderknechtEHumbelREThe amino acid sequence of insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem1987; 253: 269–6
2.
FurlanettoRWUnderwoodLEVan WykJJD'ErcoleAJEstimation of somatomedin-C levels in normals and patients with pituitary disease by radioimmunoassay. J Clin Invest1977; 60: 648–57
3.
HintzRLLiuFA radioimmunoassay for insulin-like growth factor 11 specific for the C-peptide region. J Clin Endocrinol Metab1982; 54: 442–6
4.
FantMMunroHMosesACAn autocrine/paracrine role for the insulin-like growth factors (IGF's) in the regulation of placental cell growth. J Clin Endocrinol Metab1986; 63: 499–505
5.
ScottCDMartinJLBaxterRCRat hepatocyte insulin like growth factor-1 and binding protein: effect of growth hormone in vitro andin vivo. Endocrinol1985; 116: 1102–7
6.
ZapfJSchoenleEJagarsGSandIGrumwaldJFroeschERInhibition of the activity of non-suppressible insulin-like activity on isolated rat fat cells by binding to its carrier protein. J Clin Invest1979; 63: 1077–84
7.
PovoaGRooveteAHallKCross-reaction of serum somatomedin-binding protein in a radioimmunoassay developed for somatomedin-binding protein isolated from human amniotic fluid. Acta Endocrinol (Copenh)1984; 107: 563–70
8.
RutanenE-MKoistinenRWahlstromTBohnHSeppalaMThe content of placental protein 12 in decidua and fetal membranes is greater than in the placenta. Brit J Obstet Gynaecol1984; 91: 1240–4
9.
WhittakerPGStewartMOTaylorAHowellRJSLindTInsulin-like growth factor-1 and its binding protein-1 during normal and diabetic pregnancies. Obstet Gynecol1990; 76: 223–9
10.
ThanGNCsabaIFSzaboDGAranyAABognarZJBohnHSerum levels of placenta-specific tissue protein 12 (PP12) in pregnancies complicated by preeclampsia, diabetes or twins. Arch Gynecol1984; 236: 41–5
BaxterRCBrownASTurtleJRRadioimmunoassay for somatomedin C: comparison with radioreceptor assay in patients with growth-hormone disorders, hypothyroidism and renal failure. Clin Chem1982; 28: 488–95
14.
SnedecorGWCochranWG In Statistical Methods.Ames: Iowa State University Press, 1967; 59
15.
RutanenE-MBohnHSeppalaMRadioimmunoassay of placental protein 12 levels in amniotic fluid, cord blood and serum of healthy adults, pregnant women and patients with trophoblastic disease. Am J Obstet Gynecol1982; 144: 460–3
16.
HallKHannsonULundinGLuthmanMPerssonBPovoaGSerum levels of somatomedins and somatomedin binding protein in pregnant women with type 1 or gestational diabetes and their infants. J Clin Endocrinol Metab1986; 63: 1300–6
17.
SuikkariA-MKoivistoVARutanenE-MYki-JarvinenHKaronenS-LSeppalaMInsulin regulates the serum levels of low molecular weight insulin-like growth factor-binding protein. J Clin Endocrinol Metab1988; 66: 266–72
18.
BaldwinSChungTRogersMChardTWangHSInsulin-like growth factor binding protein-1, glucose tolerance and fetal growth in human pregnancy. J Endocr1993; 136: 319–25
19.
GulerH-PZapfJFroeschERShort term metabolic effects of recombinant insulin-like growth factor I in healthy adults. N Engl J Med1987; 317: 137–4
20.
RitvosORantaTJalkanenJSuikkariA-MVoutilainenRBohnHInsulin-like growth factor (IGF) binding protein from human decidua inhibits the binding and biological action of IGF-I in cultured choriocarcinoma cells. Endocrinology1988; 122: 2150–7
21.
ElginRGBusbyWHClemmonsDRAn insulin-like growth factor binding protein enhances the biologic response to IGF-I. Proc Natl Acad Sci USA1987; 84: 3313–8
22.
ConoverCALeePDKInsulin regulation of insulin-like growth factor-binding protein production in HepG2 cells. J Clin Endocrinol Metab1990; 70: 1062–7
23.
PekonenFSuikkariA-MMakinenTRutanenE-MDifferent insulin-like growth factor binding species in human placenta and decidua. J Clin Endocrinol Metab1988; 67: 1250–7
24.
ChochinovRHMarizIKHajekASDaughadayWHCharacterization of a protein in mid-term human amniotic fluid which reacts in the somatomedin-C radioreceptor assay. J Clin Endocrinol Metab1977; 44: 902–8
25.
RutanenE-MPekonenFMakinenTSoluble 34K binding protein inhibits the binding of insulin-like growth factor I to its cell receptors in human secretory phase endometrium. J Clin Endocrinol Metab1988; 66: 173–80
26.
CotterillAMCowellCTBaxterRCMcNeilDSilinikMRegulation of the growth hormone-independent growth factor-binding protein in children. J Clin Endocrinol Metab1988; 67: 882–7
