Random urine samples were obtained from 16 healthy subjects (nine men and seven women) before and after a 100 Km hill walk for the estimation of total protein, albumin, N-acetyl-β-glucosaminidase (NAG), retinol binding protein (RBP) and creatinine. The excretion of total protein, albumin and NAG (expressed in relation to creatinine excretion) increased significantly after the walk. The relative clearance of protein and albumin also increased. In four subjects serial measurements were made for 4 days and the excretion of albumin and NAG on the fourth day were similar to the pre-walk values. We conclude that proteinuria of prolonged exercise is at least partly due to reduced tubular reabsorption.
MogensenCEChristensenCK. Predicting diabetic nephropathy in insulin dependent patients. N Engl J Med1984; 311: 89–93.
2.
LositoAZampiLFortunatiLDel FaveroA. Glomerular hyperfiltration and albuminuria in essential hypertension. Nephron1988; 49: 84–5.
3.
YudkinJSForrestRDJacksonCA. Microalbuminuria as a predictor of vascular disease in non-diabetic subjects. Lancet1988; ii: 530–3.
4.
PoortmansJR. Exercise and renal function. Sports Med1984; 1: 125–53.
5.
WalkerKVWardKHMahanLDWilsmattDK. Current concepts in proteinuria [Review]. Clin Chem1989; 35: 755–65.
6.
PoortmansJRLabilloyD. The influence of work intensity on postexercise proteinuria. Eur J Appl Physiol1988; 57: 260–3.
7.
PoortmansJR. Postexercise proteinuria in humans. Facts and mechanisms. JAMA1985; 253: 236–40.
8.
PoortmansJREnglesMFLabilloryDNisetG. The influence of the type of activity upon postexercise proteinuria in man. Med Sci Sports Exer1982; 14: 118.
9.
ClericoAGiammatteiCCecchiniLLucchettiACruschelliLPennoGExercise-induced proteinuria in well-trained atheletes. Clin Chem1990; 36: 562–4.
10.
AlvarezGMirJObayaSFragosoM. Hematuria and microalbuminuria after a 100 kilometer race. Am J Sports Med1987; 15: 609–11.
11.
KramerBKKernzMRessKMPfohlMMullerGASchmullingRMInfluence of strenuous exercise on albumin excretion. Clin Chem1988; 34: 2516–8.
12.
PoortmansJR. Effect of exercise on the renal clearance of amylase and lysozyme in humans. Clin Sci1972; 43: 115–20.
13.
PoortmansJRVancalckB. Renal glomerular and tubular impairment during strenuous exercise in young women. Eur J Clin Invest1978; 8: 175–8.
14.
CheungCKYeungVTFCockramCSSwaminathanR. Urinary excretion of albumin and enzymes in non-insulin dependent Chinese diabetics. Clin Nephrol1990; 24: 125–30.
15.
CheungCKSwaminathanR. Automated methods for the determination of retinol-binding protein, prealbumin and transferrin in urine. Clin Biochem1989; 22: 425–7.
16.
CheungCKLaoTSwaminathanR. Urinary excretion of some proteins and enzymes during normal pregnancy. Clin Chem1989; 35: 1978–80.
17.
LucertiniSValcaviPMultiAFranchiniI. Enzyme-linked immunosorbent assay for retinol-binding protein in serum and urine. Clin Chem1984; 30: 149–51.
18.
Al-HouhalaI. Effects of exercise on glomerular passage of macromolecules in patients with diabetic nephropathy and in healthy subjects. Scand J Clin Lab Invest1990; 50: 27–33.
19.
PoortmansJRJourdainMHeytersCReardonFD. Postexercise proteinuria in rowers. Can J Sport Sci1990; 15: 126–30.
20.
PoortmansJRRampaerLWolfsJC. Renal protein excretion after exercise in man. Eur J Appl Physiol1989; 58: 476–80.
21.
HouserMT. Characterization of recumbent, ambulatory and postexercise proteinuria in the adolescent. Pediatr Res1987; 21: 442–6.
22.
TorffvitOCastenforsJBengtssonUAgardhCD. Exercise stimulation in insulin-dependent diabetes, normal increase in albuminuria with abnormal blood pressure response. Scand J Clin Lab Invest1987; 47: 253–9.
23.
PoortmansJRJeanlozRW. Quantitative immunological determination of twelve plasma proteins excreted in human urine collected before and after exercise. J Clin Invest1968; 47: 386–93.
LeiperKBMcCormickKRobertsonJDWhitingPHMaughanRD. Fluid homeostasis during prolonged low-intensity walking on consecutive days. Clin Sci1988; 75: 63–70.
28.
WatanabeYNunoiKMakiUNakamuraYFujishimaM. Contribution of glycaemic control to the levels of urinary N-acetyl-β-D-glucosaminidase (NAG), total protein, β2-microglobulin and serum NAG in type 1 (insulin-dependent) diabetes mellitus without macroalbuminuria. Clin Nephrol1987; 28: 227–31.
29.
JungKPergandeMSchimkeERatzmannKPIlliusA. Urinary enzymes and low molecular mass proteins as indicators of diabetic nephropathy. Clin Chem1988; 34: 544–7.
30.
PoortmansJRBraumanHStaroukineMVernioryADecaesteckerCLechercqR. Indirect evidence of glomerular tubular mixed-type postexercise proteinuria in healthy humans. Am J Physiol1988; 254: F277–83.
