Serum alkaline phosphatase (ALP) activity was found to be grossly elevated (8594 U/L) in a 2-year-old female child, returning towards normal during the subsequent 2 months. Electrophoresis revealed two bands of ALP activity; isoenzyme analysis identified the cathodic band as being of bone origin and the anodic band as sialylated liver ALP. Whilst the aetiology of transient hyperphosphataemia remains unclear a probable allergic disorder appears to be a contributory factor in this patient.
SteinPRosalkiSBYingFoo AHjelmM. Transient hyperphosphatasemia of infancy and early childhood: Clinical and biochemical features of 21 cases and literature review. Clin Chem1987; 33: 313–18.
2.
CroftonPM. What is the cause of benign transient hyperphosphatasemia? A study of 35 cases. Clin Chem1988; 34: 335–40.
3.
MaekawaMOkamotoAIwaharaKKannoT. Incidence and clinical characteristics of transient hyperphosphatasemia in children. Jpn J Clin Pathol1989; 37: 279–84.
MossDWPanovEYWhitakerKB. The effect of biliary obstruction on some properties of alkaline phosphatase of rat liver. Clin Chim Acta1974; 51: 41–6.
6.
RosalkiSB. Association of Clinical Biochemists' Working Party recommendations: Proposed methods for determinations of some enzymes in blood serum. Assoc Clin Biochem News Sheet1980; (Suppl) 9–12.
7.
RosalkiSBYingFoo A.Two new methods for separating and quantifying bone and liver alkaline phosphatase isoenzymes in plasma. Clin Chem1984; 30: 1182–6.
8.
KobayashiNUedaKTsutsumiMTabataYShimadaK.Analytical method of vitamin D (IV); Development of an enzyme immunoassay for 25-hydroxyvitamin D3. In: The 110 Congress of Japan Pharmacological Society August; Abstract, Sapporo, Japan. 1990; (3) 272.
HyldstrupLClemmensenIJensenBATransbølI. Non-invasive evaluation of bone formation: measurements of serum alkaline phosphatase, whole body retention of diphosphonate and serum osteocalcin in metabolic bone disorders and thyroid disease. Scand J Clin Lab Invest1988; 48: 611–19.
14.
WatersonMJMillsRJ. Transient hyperphosphatasaemia of infancy in a young haemophiliac. Ann Clin Biochem1988; (Suppl): 199s–200s.
15.
ColeDEC. Transient hyperphosphatasemia in a child with autosomal recessive vitamin D dependency. Clin Chem1986; 32: 1418–19.
