Malignant laryngeal neoplasms in children are uncommon and present diagnostic and therapeutic challenges. A 15-year retrospective review of laryngeal tumors at our institution identified four patients with malignant neoplasms. These children, 7 months to 16 years of age, were treated for squamous cell carcinoma, choriocarcinoma, rhabdomyosarcoma, and primitive neuroectodermal tumor. This report details these cases, emphasizing diagnostic approaches, treatment decisions (medical oncologic management, surgical resection), and rehabilitation measures for postlaryngectomy communication. A multi-institutional pediatric head and neck tumor registry would be a useful reference to assist with individual treatment decisions.
HealyGBUptonJBlackPMcLFerraroN. The role of surgery in rhabdomyosarcoma of the head and neck in children. Arch Otolaryngol Head Neck Surg1991; 117: 1185–8.
2.
WardRFHealyGB. Neoplasia of the pediatric larynx. In: FriedM, ed. The larynx: a multidisciplinary approach. Boston, Mass: Little, Brown, 1988: 163–9.
3.
GindhartTDJohnstonWHChismSEDedoHH. Carcinoma of the larynx in childhood. Cancer1980; 46: 1683–7.
4.
ZalzalGHCottonRTBoveK. Carcinoma of the larynx in a child. Int J Pediatr Otorhinolaryngol1987; 13: 219–25.
5.
CohenSRThompsonJWSiegelSE. Non-Hodgkin's lymphoma of the larynx in children. Ann Otol Rhinol Laryngol1987; 96: 357–61.
6.
MitchellDBHumphreysSKearnsDB. Mucoepidermoid carcinoma of the larynx in a child. Int J Pediatr Otorhinolaryngol1988; 15: 211–5.
7.
RaneyRBHaysDMTefftMTricheTJ. Rhabdomyosarcoma and the undifferentiated sarcomas. In: PizzoPAPoplackDG, eds. Principles and practice of pediatric oncology. Philadelphia, Pa: JB Lippincott, 1993: 769–94.
8.
KatoMADPFlamantFTerrier-LacombeMJ. Rhabdomyosarcoma of the larynx in children. Med Pediatr Oncol1991; 19: 110–4.
9.
MaurerHM. The Intergroup Rhabdomyosarcoma Study (NIH): Objectives and clinical staging classification. J Pediatr Surg1975; 10: 977–8.
HorowitzMEDeLaneyTFMalawerMMTsokosMG. Ewing's sarcoma family of tumors: Ewing's sarcoma of bone and soft tissue and the peripheral primitive neuroectodermal tumors. In: PizzoPAPoplackDG, eds. Principles and practice of pediatric oncology. Philadelphia, Pa: JB Lippincott, 1993: 795–821.
12.
JurgensHBierVHarmsD. Malignant peripheral neuroectodermal tumors: A retrospective analysis of 42 patients. Cancer1988; 61: 349–57.
13.
LaurianNSadovRStraussMKesslerE. Laryngeal carcinoma in childhood. Report of a case and review of the literature. Laryngoscope1984; 94: 684–7.
14.
PandeyRChoudhuryC. Case report of cancer of the larynx in an adolescent. J Laryngol Otol1968; 82: 469–71.
15.
SethRRSYadavYCKalaDM. Epidermoid carcinoma of the laryngopharynx in a young girl. J Laryngol Otol1978; 92: 925–6.
16.
OssoffRHTuckerGFNorrisCM. Carcinoma of the larynx in an 11-year-old boy with late cervical metastasis: Report of a case with a ten-year follow-up. Otolaryngol Head Neck Surg1980; 88: 142–5.
17.
The Department of Veterans Affairs Laryngeal Study Group.Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med1991; 324: 1685–90.
18.
MerlanoMVitaleVRossoR. Treatment of advanced squamous-cell carcinoma of the head and neck with alternating chemotherapy and radiotherapy. N Engl J Med1992; 327: 1115–21.
19.
ShirinianMHWeberRSLippmanSM. Laryngeal preservation by induction chemotherapy plus radiotherapy in locally advanced head and neck cancer: The M. D. Anderson Cancer Center experience. Head Neck1994; 16: 39–44.
20.
ShimizuKTSelchMTFuY-SAnzaiYLufkinRB. Osteosarcoma metastatic to the larynx. Ann Otol Rhinol Laryngol1994; 103: 160–3.
21.
AblinAIsaacsH. Germ cell tumors. In: PizzoPAPoplackDG, eds. Principles and practice of pediatric oncology. Philadelphia, Pa: JB Lippincott, 1993: 867–87.
22.
BenjaminB. Congenital disorders of the larynx. In: CummingsCWFredricksonJMHarkerLAKrauseCJSchullerDE, eds. Otolaryngology—head and neck surgery. St Louis, Mo: Mosby—Year Book, 1993: 1831–53.
