Laryngeal liposarcoma is an unusual tumor. Only 16 cases have been previously reported. We describe a new case of well-differentiated laryngeal liposarcoma and review the literature. The tumor was treated by surgical removal. Immunohistochemical study showed an immunophenotype consistent with liposarcoma. The case described is of the oldest patient (83 years old), the second to be found in a woman, and the second to be localized to one true vocal cord (according to the literature reviewed). The patient is still free of tumor 2 years later. The treatment and prognosis of liposarcoma of the larynx are discussed.
WenigBMWeissSWGneppDR. Laryngeal and hypopharyngeal liposarcoma: A clinicopathologic study of 10 cases with a comparison to soft-tissue counterparts. Am J Surg Pathol1990; 14: 134–41.
3.
WeissSWRaoVK. Well-differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum, and miscellaneous sites. A follow-up study of 92 cases with analysis of the incidence of “dedifferentiation.”. Am J Surg Pathol1992; 16: 1051–8.
4.
MiettinenM. Immunohistochemistry of soft-tissue tumors. Pathol Annu1990; 25: 1–36.
5.
MillerDGoodmanMWeberAGoldsteinA. Primary liposarcoma of the larynx. Trans Am Acad Ophthalmol Otolaryngol1975; 80: 444–7.
6.
VelekJP. Liposarcoma of the larynx. Trans Am Acad Ophthalmol Otolaryngol1976; 82: 569–70.
7.
KrausenASGallAMGarzaRSpectorGJAnselDG. Liposarcoma of the larynx: A multicentric or a metastatic malignancy. Laryngoscope1977; 87: 1116–24.
8.
FerlitoA. Primary pleomorphic liposarcoma of the larynx. J Otolaryngol1978; 7: 161–6.
9.
TobeyDNWheelisRFYaringtonCTJr. Electron microscopy in the diagnosis of liposarcoma and fibrosarcoma of the larynx. Ann Otol Rhinol Laryngol1979; 88: 867–71.
10.
ShahMCLowryLD. Primary liposarcoma of the larynx. Trans Pa Acad Ophthalmol Otolaryngol1984; 37: 49–52.
11.
GaynorEBRaghausanUWeisbrotIM. Primary mixoid liposarcoma of the larynx. Otolaryngol Head Neck Surg1984; 92: 476–80.
12.
AllsbrookWCHarmonJDChongchitnantNErwinS. Liposarcoma of the larynx. Arch Pathol Lab Med1985; 109: 294–6.
13.
MeisJMMacKayBGoepfertH. Liposarcoma of the larynx. Case report and literature review. Arch Otolaryngol Head Neck Surg1986; 112: 1289–92.
14.
GertnerRPodoshinLFradisMMisselevitchIBossJ. Liposarcoma of the larynx. J Laryngol Otol1988; 102: 838–41.
15.
EnzingerFMWinslowDJ. Liposarcoma: A study of 103 cases. Virchows Arch [A]1962; 335: 367–88.
16.
EvansHL. Liposarcoma: A study of 55 cases with a reassessment of its classification. Am J Surg Pathol1979; 3: 507–23.
17.
ReitanJBKaalhusOBrennhovdIOSagerEMStenwigAETalleK. Prognostic factors in liposarcoma. Cancer1985; 55: 2482–90.
18.
CelikCKarakousisCPMooreRHolyokeED. Liposarcomas: Prognosis and management. J Surg Oncol1980; 14: 245–9.
