Two immunocompromised patients with severe neutropenia developed acute airway obstruction due to Aspergillus mycetoma formation in the trachea and main bronchi. The mycetomas caused transmural necrosis of the airway. In one patient, the necrosis extended through the bronchus intermedius into the pulmonary artery, resulting in a fatal hemorrhage during bronchoscopy.
PetersonPKMcGlavePRamsayNK. A prospective study of infectious diseases following bone marrow transplantation: Emergence of Aspergillus and cytomegalovirus as the major causes of mortality. Infect Control1983; 4: 81–9.
2.
BerlingerNT. Sinusitis in immunodeficient and immunosuppressed patients. Laryngoscope1985; 95: 29–33.
3.
SchubertMMPetersonDEMeyersJDHackmanRThomasD. Head and neck aspergillosis in patients undergoing bone marrow transplantation. Cancer1986; 57: 1092–6.
PervezNKKleinermanJRattanM. Pseudomembranous necrotizing bronchial aspergillosis: A variant of invasive aspergillosis in a patient with hemophilia and acquired immune deficiency syndrome. Am Rev Respir Dis1985; 131: 961–3.
6.
PrzyjemskiCMattiiR. The formation of pulmonary mycetomata. Cancer1980; 46: 1701–4.
NalesnikMAMyerowitzRLJenkinsRLenkeyJHerbertD. Significance of Aspergillus species isolated from respiratory secretions in the diagnosis of invasive pulmonary aspergillosis. J Clin Microbiol1980; 11: 370–6.
