Age-related hair cell loss has been studied in squirrel monkeys using surface preparation of the organ of Corti. Increasing hair cell loss starting at the apex is seen as a function of age. This finding is discussed in the light of our studies in guinea pigs, chinchillas, and rabbits. Reviewed with other human and experimental data, it would appear that many species of animals have age-related histological damage similar to that seen in the human organ of Corti.
CroweSJGuildSRPolnogtLM. Observation of the pathology of high-tone deafness. Bull Johns Hopkins1934; 34: 315–84
6.
SaxenAvan FieandtH. Pathologie und Klinik der Alters-schwerhörigkeit. Acta Otolaryngol [Suppl] (Stockh) 1937 (suppl 23)
7.
SchuknechtHF. Further observations on the pathology of presbycusis. Arch Otolaryngol1964; 80: 369–82
8.
SchuknechtHF. Pathology of the ear.Cambridge, Mass: Harvard University Press, 1974: 388–403
9.
BredbergG. Cellular pattern and nerve supply of the human organ of Corti. Acta Otolaryngol [Suppl] (Stockh) 1968 (suppl 236)
10.
JohnssonL-GHawkinsJEJr. Sensory and neural degeneration with aging, as seen in microdissections of the human inner ear. Ann Otol Rhinol Laryngol1972; 81: 179–93
11.
DumNSchmidtUvon WedelH. Age-dependence of the neural auditory thresholds of albino and pigmented guinea pigs. Arch Otorhinolaryngol1980; 229: 191–9
12.
KeithleyEMFeldmanML. Hair cell counts in an agegraded series of rat cochleas. Hear Res1982; 8: 249–62
13.
CovellWPRogersJB. Pathologic changes in the inner ears of senile guinea pigs. Laryngoscope1957; 67: 118–29
14.
CrowleyDESchrammVLSwainREMaiselRHRauchbachESwansonSN. An animal model for presbycusis. Laryngoscope1972; 82: 2079–91
15.
UlehlovaL. Normal cellular pattern of the organ of Corti in the guinea pig. Arch Klin Exp Ohren Nasen Kehlkopfheilkd1973; 204: 321–30
16.
HawkinsJEMillerJMRouseRCDavisJARareyK. Inner ear histopathology in aging rhesus monkey (Macaca mulatta). In: DavisRTLeathersCW eds. Behavior and pathology of aging in rhesus monkeys.New York: Alan R. Liss, 1985: 137–54
17.
DayalVSBarekWG. Cochlear changes from noise, kanamycin and aging. Laryngoscope1975; 85 (suppl 1): 1–18
18.
BhattacharyyaTKDayalVS. Age-related cochlear hair cell loss in the chinchilla. Ann Otol Rhinol Laryngol1985; 94: 75–80
19.
WrightJLSchuknechtHF. Atrophy of the spiral ligament. Arch Otolaryngol1972; 96: 16–21
20.
TakahashiT. The ultrastructure of the pathologic stria vascularis and spiral prominence in man. Ann Otol Rhinol Laryngol1971; 80: 721–35
21.
DayalVSKaneNMendelsohnM. Patterns of pure tone hearing loss. Acta Otolaryngol (Stockh)1970; 69: 329–32
22.
SchuknechtHFNeffWD. Hearing losses after apical lesions in the cochlea. Acta Otolaryngol (Stockh)1952; 42: 263–74
23.
HenryKRMcGinnMDCholeRA. Age-related auditory loss in the Mongolian gerbil. Arch Otorhinolaryngol1980; 228: 233–8
