Rats were immunized with native type II bovine collagen to induce antoimmune inner ear disease, and the antibody activity in the inner ear fluid was measured. Antibody activity against type II collagen was detected in the perilymph at about 10% to 20% of serum level. Thus, the presence of antibody against type II collagen in inner ear fluid may imply an immune injury mechanisn in inner ear diseases.
McCabeB. Autoimmune sensorineural hearing loss. Ann Otol Rhinol Laryngol1979; 88:585–9.
2.
YooTJTomodaKStuartJMCremerMATownesASKangAH. Type II collagen-induced autoimmune sensorineural hearing loss and vestibular dysfunction in rats. Ann Otol Rhinol Laryngol1983; 92:267–72.
3.
Rask-AndersonHStahleJ. Immunodefense of the inner ear? Lymphocyte-macrophage interaction in the endolymphatic sac. Acta Otolaryngol (Stockh)1980; 89:283–94.
4.
MogiGLimDJWatanabeN. Immunologic study on the inner ear: Immunoglobulins in perilymph. Arch Otolaryngol1982; 108:270–5.
5.
YooTJTomodaKHernandezA. Type II collagen-induced autoimmune inner ear lesions in guinea pigs. Ann Otol Rhinol Laryngol1984; 93 (Suppl 113):3–5.
6.
TrelstadRLKangAHTooleBPGrossJ. Collagen heterogenecity: High resolution of native [α1 (I)] α2 and [αI (II)]3 and their component α chains. J Biol Chem1973; 247:6469–73.
7.
TomodaKYooTJ. Type II collagen distribution in the inner ear [Abstract]. Presented at the Midwinter Research Meeting, Assoc Res Otolaryngol, St Petersburg, Fla, January 1983.
8.
YooTJStuartJMKangAHTownesASTomodaKDixitS. Type II collagen autoimmunity in otosclerosis and Meniere's disease. Science1982; 217:1153–5.
