XIX Studies with Steam Generated Aerosols

Abel J. J. Crawford A. C. : On the Blood-pressure Raising Constituent of the Suprarenal Capsule, Bull. Johns Hopkins Hospital 8: 151, 1897.

Bullowa J. G. M. Kaplan D. : Hypodermic Use of Adrenalin Chloride in the Treatment of Asthmatic Attacks, Med. News 83: 787, 1903.

Graeser J. B. Rowe A. H. : Inhalation of Epinephrine for Relief of Asthmatic Symptoms, J. Allergy 6: 415, 1935.

Richards D. W. Barach A. L. Cromwell H. A. : Use of Vaporized Bronchodilator Solutions in Asthma and Emphysema: Continuous Inhalation Method for Severe Asthmatic States, Am. J. Med. Sci. 199: 225, 1940.

Abramson H. A. : Improved Inhalation Therapy of Asthma, Arch. Phys. Therapy 21: 612, 1940.

Stacey J. W. : Inhalation of Nebulized Solutions of Sulfonamides in the Treatment of Bronchiectasis, Dis. Chest 9: 302, 1943.

Applebaum L. I. : The Treatment of Bronchial Lesions by Inhalation of Nebulized Solutions of Sodium Sulfathiazole, Dis. Chest 10: 415, 1944.

Chapple C. C. Lynch H. M. : A Study of Sulfonamide Aerosol Inhalation, Am. J. Med. Sci. 207: 408, 1944.

Bryson V. Sansome E. Laskin S. : Aerosolization of Penicillin Solutions, Science 100: 23, 1944.

Prigal S. J. Speer F. D. : A New Method of Aerosolization of Penicillin and Other Medicaments for Inhalation Therapy, Bull. N. Y. Med. College 8: 21, 1945.

Barach A. L. Silberstein F. H. Oppenheimer E. T. Hunter T. Saroka M. : Inhalation of Penicillin Aerosol in Patients with Bronchial Asthma, Chronic Bronchitis, Bronchiectasis and Lung Abscesses, Ann. Int. Med. 22: 485, 1945.

Olsen A. M. : Streptomycin Aerosol in the Treatment of Chronic Bronchiectasis, Proc. Staff Meeting, Mayo Clinic 21: 53, 1946.

Prigal S. J. Furman M. L. : The Use of Bacitracin: A New Antibiotic in Aerosol Form, Ann. Allergy 7: 662, 1949.

Prigal S. J. : Aerosol Therapy in the Practice of Allergy, J. Allergy 22: 50, 1951.

Barach A. L. Garthwaite B. Rule C. : Penicillin Aerosol in Bronchopulmonary and Sinus Infections, N. Y. State J. Med. 46: 1703, 1946.

Segal M. S. Levinson L. Miller D. : Penicillin Inhalation Therapy in Respiratory Infections, J. A. M. A. 134: 762, 1947.

Segal M. S. Beakey J. F. Bresnick E. Levinson L. : A Comparative Study of the Action of Various Sympathomimeticamine Aerosols in Counteracting the Dyspnoea and Bronchospasm Induced by Histamine and Acetyl-beta-methylcholine, J. Allergy 20: 97, 1949.

Gaensler E. Beakey J. F. Segal M. S. : The Pharmaco-dynamics of Pulmonary Absorption in Man. Aerosol and Intratracheal Penicillin, Ann. Int. Med. 31: 582, 1949.

Bryson V. Grace E. J. : Aerosol Therapy of Respiratory Disease. Report of 50 Cases, New Eng. J. Med. 237: 683, 1947.

Abramson H. A. : Aerosol Therapy of the Lungs and Bronchi with Special Reference to Penicillin and Hydrogen Peroxide, Bull. New Eng. Med. Center 8: 97, 1946.

Finke W. : Simplification of Penicillin Aerosol Therapy for Home Treatment, Am. Pract. 1: 643, 1947.

Finke W. : Personal communication to the author.

Prigal S. J. McGavack T. H. Speer F. D. Harris R. : Aerosol Penicillin: Blood Levels of Penicillin Obtained by Inhalation of Aerosols Produced by a Combined Steam Generator and Aerosolizer with the Use of Propylene Glycol, Tents and a Breathing Box, J. A. M. A. 134: 932, 1947.

Prigal S. J. Morganbesser L. J. McIntyre F. P. : Penicillin Aerosol in the Prevention and Treatment of Respiratory Infections in Allergic Patients, J. Allergy 18: 325, 1947.

Prigal S. J. : Studies with Medicated Aerosols: The Use of the Lungs as a Portal for the Introduction of Therapeutic Agents for Systemic Effect, Ann. Int. Med. 28: 814, 1948.

Prigal S. J. Brooks A. M. Harris R. : The Treatment of Asthma by Inhalation of Aerosol of Aminophylline, J. Allergy, 18: 16, 1947.

Taplin G. V. Bryan F. A. : The Administration of Micronized Therapeutic Agents by Inhalation or Topical Application, Science 105: 502, 1947.

Krasno L. Karp M. Rhodes P. S. : Inhalation of Penicillin Dust, Science 106: 249, 1947.

Krasno L. Grossman M. Ivy A. C. : The Inhalation of Norisodrine Sulfate Dust, Science 108: 476, 1948.

Taplin G. V. Gropper A. L. Scott G. : Micropowdered Aminophylline or Theophylline Inhalation Therapy in Chronic Bronchial Asthma; Evaluation by Recorded Vital Capacity Changes, Ann. Allergy 7: 513, 1949.

Cohen S. Taplin G. V. Mahoney E. B. : Inhalation of Micropowdered Penicillin and Streptomycin in the Prevention of Postoperative Pulmonary Infection, Surgery 24: 392, 1948.

Prigal S. J. Wilson I. : Unpublished data.

Rooth G. : Inhalation of Liquid Aerosols, Supplement of Acta, Med. Scand. Lund, 1949.

Prigal S. J. : A Combined Steam Generator and Aerosolizer. The production of Aerosols of Penicillin, Sulfadiazine, Aminophylline and Other Medications in Solution, J. A. M. A. 131: 398, 1946.

Barach A. L. Garthwaite B. : The Use of Penicillin Aerosol in Bronchopulmonary and Sinus Infections, N. Y. J. Med. 46: 1703, 1946.

Beakey J. F. Gaensler E. A. Segal M. S. : A Comparative Study of Various Apparatus and Techniques for Aerosol Administration, Conn. Med. J. 13: 855, 1949.

Quoted by Rooth.³³

Ferlauto R. J. Clymer H. A. : Stability of Penicillin in Glycerin and Glycols, Sci. 105: 2718, 1947.

Prigal S. J. Tchertkoff V. Brooks A. M. : Blood Levels of Streptomycin Obtained by Inhalation of Aerosols Produced by a Combined Steam Generator and Aerosolizer, Dis. Chest 17: 304, 1950.

Benson R. L. Perlman J. : Clinical Effects of Epinephrine by Inhalation, J. Allergy 19: 129, 1948.

Yonkman F. F. Levinson L. Segal M. S. : An Approach to the Problem of “Epinephrine-fastness,” Am. J. Digest Dis. 17: 149, 1950.

Segal M. S. Rubitsky H. J. Bresnick E. Levinson L. : Evaluation of Solid (“Dust”) Aerosols as Therapeutic Agents, Ann. Allergy 9: 53, 1951.

Prigal S. J. Molomut N. : Bacteriologic and Epidemiologic Approach to the Treatment of Respiratory Infections with Antibiotic Aerosols, J. A. M. A. 144: 897, 1950.

Castex M. Capedehourat E. Lavarella A. : Tecnia de las nebulizacioner y sus principales ventajas terapeuticas, Prens. Med. Argent. 28: 2663, 1940.

Prigal S. J. McGavack T. H. Bell M. : The Effect of Propylene Glycol on the Antibiotic Activity of Human Serum, Am. J. Med. 3: 185, 1947.

Lillich L. Prigal S. J. Boyd L. J. : The Effect of Plasma-Propylene Glycol Mixtures Upon Certain Bacteria, Submitted for Publication.

Johnson B. A. Anker H. Meleney F. L. : Bacitracin, a New Antibiotic Produced by a Number of the B. Subtilis Group, Science 102: 376, 1945.

Applebaum E. Leff W. A. : Occurrence of Superinfection During Antibiotic Therapy, J. A. M. A. 138: 119, 1948.

Jawetz E. Gunnison J. B. Speck R. S. Coleman V. R. : Studies on Antibiotic Synergism and Antagonism; the Interference of Chloramphenicol with the Action of Penicillin, Arch. Int. Med. 87: 349, 1951.

Woods J. W. Manning I. H. Patterson C. N. : Monilial Infections Complicating the Therapeutic Use of Antibiotics, J. A. M. A. 145: 207, 1951.

Keeney E. L. : Candida Asthma, Ann. Int. Med. 34: 223, 1951.

Feinberg S. M. Bernstein T. B. : Nebulized Pyribenzamine in Nasal and Bronchial Allergy, J. Lab. and Clin. Med. 34: 1078, 1949.

Literature supplied by Eli Lilly & Co., on Aerolin Compound.

Reeder W. H. Mackey G. S. : Nebulized Cortisone in Bacterial Pneumonia, Dis. Chest 18: 528, 1950.

Prigal S. J. : The Integration of the Practice of Allergy and Psychiatry, Ann. Allergy, 6: 669, 1948.

Johnson B. A. Meleney F. O. : Studies on the Synergism Between Bacitracin and Penicillin: Correlation of In Vivo and In Vitro Results, Ann. N. Y. Acad. Sci. 53: 42, 1950.

Barach A. L. Garthwaite B. Rule C. Talbot R. Kernan J. D. Babcock J. Brown G. : Penicillin Aerosol and Negative Pressure in the Treatment of Sinusitis, Am. J. Med. 1: 268, 1946.

Data to be published.

Prigal S. J. Molomut N. : The Bacteriologic and Epidemiologic Approach to the Treatment of Sino-Respiratory Infections. Series 11: Observations on Efficacy of Antibiotics with Continued Use, A. M. A. Arch. of Otolaryngology 54: 493, 1951.

Abramson H. A. Reiter C. Sklarofsky B. Gettner H. H. : Standardization Procedure for Determination of Aerosol Delivery of Nebulizers by Phenosulfonpthalein Aerosols, Ann. Allergy 7: 390, 1949.

Prigal S. J. : Letter to the Editor: Bacteriologic Environment in Chronic or Repeated Infections, J. A. M. A. 144: 1585, 1951.

Finke W. : Prospects for Prevention of Chronic Bronchitis and Bronchiectasis, J. Ped. 33: 29, 1948.

Taplin G. V. Cohen S. H. Mahoney E. B. : Prevention of Postoperative Pulmonary Infections, Inhalation of Micropowdered Penicillin and Streptomycin, J. A. M. A. 138: 4, 1948.

Abramson H. A. : Penicillin Aerosols of High Concentration, Science 106: 316, 1947.

Quoted by Rooth.³³

Van Wigh A. M. Patterson H. S. : The Parentage of Particles of Different Sizes Removed from Dustladen Air by Breathing, J. Indust. Hyg. and Toxicol. 22: 31, 1940.

Abramson H. A. : Principles and Practice of Aerosol Therapy of the Lungs and Bronchi, Ann. Allergy 4: 440, 1946.

Sloan J. Q. Bain G. P. Brucer M. : Depth of Penetration of Nebulized Substances in the Respiratory Tree, Proc. Soc. Exp. Bio. and Med. 66: 264, 1947.

Barach A. L. Molomut N. Soroka M. : Inhalation of Nebulized Promin in Experimental Tuberculosis, Am. Rev. Tuberc. 46: 268, 1942.

Wilson C. E. Hammond C. W. Byrne A. F. : The Control of Experimental Pneumonia with Penicillin. 1: Comparison of Inhalation and Injection Therapy, Bull. Johns Hopkins Hosp. 77: 411, 1947.

Talbot R. Quimley E. Barach A. : A Method of Determining the Site of Retention of Aerosols Within the Respiratory Tract of Man by the Use of Radioactive Sodium, Am. J. Med. Sci. 214: 505, 1947.

Harvey B. C. H. : Simple Lessons in Anatomy, Am. Med. Assoc., 1932.

Kreuger A. : The Inhalatory Route for Prophylaxis and Treatment of Experimental Influenza: The Distribution of Inhaled Material; Immune Serum in Prophylaxis and treatment, Am. J. Med. Sci. 207: 40, 1944.

Hamilton J. G. : The Metabolism of Fission Products of the Heaviest Elements, Radiology 49: 325, 1947.

Unpublished data.

Farinas P. L. : Mucosography of the Respiratory Tract, Radiology 29: 84, 1942.

Ibid: Bronchography by Atomization, Radiology 51: 491, 1948.

Daniel J. H. Brackett F. S. : An Electrical Method for Investigating the Nature and Behavior of Small Airborne Charged Particles, J. Appl. Phys. 22: 542, 1951.