“Impact of Growth Factor Concentrate Versus Topical Steriods With Antibiotics in Type 1 Tympanoplasty”

Abstract

Background:

To evaluate and compare the treatment outcomes of using topical steroids combined with antibiotics versus growth factor concentrate in type 1 tympanoplasty for chronic otitis media (mucosal type) cases.

Materials and Methods:

The study comprised patients with chronic otitis media mucosal type, who underwent type 1 tympanoplasty. Sixty six patients were randomly divided into 3 groups, each consisting of 33 patients. In Group A, topical steroids and antibiotics were used during the procedure, while in Group B, a growth factor concentrate was used. The outcomes were assessed through postoperative otoendoscopy and air bone gap at the end of the 1st and 3rd months.

Results:

In this study, Group A (patients who underwent type 1 tympanoplasty with topical steroids and antibiotics) had a 12.1% rate of residual perforation and an 18.2% rate of reperforation after 3 months. In contrast, Group B (patients treated with growth factor concentrate) had significantly lower rates of both residual perforation (3%) and reperforation (3%). While the postoperative air-bone gap at the end of the 3rd month improved in Group B (13.58 ± 3.21 dB) compared to Group A (15.45 ± 5.11 dB), the difference was not statistically significant.

Conclusion:

Growth factor concentrate has shown better graft uptake than topical antibiotics and steroids, making it a promising treatment option for augmenting tympanic membrane repair. Its biocompatibility leads to more consistent outcomes, improving patient satisfaction, and supporting broader use in otologic surgeries.