To describe a safe and effective treatment for endobronchial Mycobacterium avium complex.
Methods:
Case report and literature review.
Results:
We present a case of endobronchial M. avium complex in a healthy child treated with serial carbon-dioxide laser excisions and antibiotic triple therapy using azithromycin, rifampin, and ethambutol. No current guideline for the treatment of these lesions in the pediatric population exists.
Conclusions:
In patients with airway impingement, serial endoscopic surgical resection combined with antibiotics can provide safe and effective management.
GriffithDEAksamitTBrown-ElliottBAet al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007;175(4):367-416.
2.
KendallBAWinthropKL.Update on the epidemiology of pulmonary nontuberculous mycobacterial infections. Semin Respir Crit Care Med. 2013;34(1):087-094.
3.
RingshausenFCApelR-MBangeF-Cet al. Burden and trends of hospitalisations associated with pulmonary non-tuberculous mycobacterial infections in Germany, 2005-2011. BMC Infect Dis. 2013;13:231.
4.
StoutJEKohW-JYewWW.Update on pulmonary disease due to non-tuberculous mycobacteria. Int J Infect Dis. 2016;45:123-134.
5.
IngenJ van.Diagnosis of nontuberculous mycobacterial infections. Semin Respir Crit Care Med. 2013;34(1):103-109.
6.
McclayJEGarciaC.Management of cervicofacial nontuberculous lymphadenitis in children. Curr Opin Otolaryngol Head Neck Surg. 2013;21(6):581-587.
7.
ZimmermannPTebrueggeMCurtisNRitzN.The management of non-tuberculous cervicofacial lymphadenitis in children: A systematic review and meta-analysis. J Infect. 2015;71(1):9-18.
8.
Iroh TamPYKlineSWardGFerrieriP.Non-tuberculous mycobacterial infection in hospitalized children: a case series. Epidemiol Infect Camb. 2015;143(15):3173-3181.
9.
NoltDMichaelsMGWaldER.Intrathoracic disease from nontuberculous mycobacteria in children: two cases and a review of the literature. Pediatrics. 2003;112(5):e434.
del Rio CamachoGSoriano GuillénLFlandes AldeyturriagaJHernández GarcíaBBernácer BorjaM.Endobronchial atypical mycobacteria in an immunocompetent child. Pediatr Pulmonol. 2010;45(5):511-513.
12.
PerissonCNathanNThierryBCorvolH.Endobronchial avium mycobacteria infection in an immunocompetent child. BMJ Case Rep. 2013;2013.
13.
GovilNThottamPJThakrarDJChiDH.Pediatric atypical mycobacterium infection presenting as wheezing and concern for foreign body aspiration. Cureus. 2016;8(2):e491.
14.
HatzenbuehlerLAStarkeJR.Common presentations of nontuberculous mycobacterial infections. Pediatr Infect Dis J. 2014;33(1):89-91.
15.
HuangJHKaoPNAdiVRuossSJ.Mycobacterium avium-intracellulare pulmonary infection in HIV-negative patients without preexisting lung disease: diagnostic and management limitations. Chest. 1999;115(4):1033-1040.
16.
SugiharaEHirotaNNiizekiTet al. Usefulness of bronchial lavage for the diagnosis of pulmonary disease caused by Mycobacterium avium-intracellulare complex (MAC) infection. J Infect Chemother. 2003;9(4):328-332.
17.
HaasWHAmthorBEngelmannGRimekDBremerHJ.Preoperative diagnosis of Mycobacterium avium lymphadenitis in two immunocompetent children by polymerase chain reaction of gastric aspirates. ET J. 1998;17(11):1016-1020.
18.
KordyFRichardsonSEStephensDLamRJamiesonFKitaiI.Utility of gastric aspirates for diagnosing tuberculosis in children in a low prevalence area: predictors of positive cultures and significance of non-tuberculous mycobacteria. Pediatr Infect Dis J. 2015;34(1):91-93.
19.
PennRSteehlerMKSokohlAHarleyEH.Nontuberculous mycobacterial cervicofacial lymphadenitis—a review and proposed classification system. Int J Pediatr Otorhinolaryngol. 2011;75(12):1599-1603.
