We report what is, to our best knowledge, the first case of chronic recurrent multifocal osteomyelitis (CRMO) in which the frontal and sphenoid bones were involved. Characterized by a prolonged and fluctuating course of osteomyelitis at different sites, CRMO is self-limited, although sequelae can occur. The diagnosis is one of exclusion. It is important to publish cases like this, because the recognition of CRMO can prevent aggressive surgical and medical treatment.
ChowLTGriffithJFKumtaSMLeungPC. Chronic recurrent multifocal osteomyelitis: A great clinical and radiologic mimic in need of recognition by the pathologist. APMIS1999; 107: 369–79.
BjorkstenBBoquistL. Histopathological aspects of chronic recurrent multifocal osteomyelitis. J Bone Joint Surg Br1980; 62: 376–80.
7.
GirschickHJHuppertzHIHarmsenDKrauspeRMuller-HermelinkHKPapadopoulosT. Chronic recurrent multifocal osteomyelitis in children: Diagnostic value of histopathology and microbial testing. Hum Pathol1999; 30: 59–65.
8.
GiedionAHolthusenWMaselLFVischerD. Subacute and chronic “symmetrical” osteomyelitis [multilingual]. Ann Radiol (Paris)1972; 15: 329–42.
9.
FoleyMRMoshfeghiDMWilsonMWHaikBGPappoASHillDA. Orbital inflammatory syndromes with systemic involvement may mimic metastatic disease. Ophthal Plast Reconstr Surg2003; 19: 324–7.
10.
SueiYTanimotoKTaguchiAWadaTIshikawaT. Chronic recurrent multifocal osteomyelitis involving the mandible. Oral Surg Oral Med Oral Pathol1994; 78: 156–62.
11.
WeiheSEufingerHTerhaarOKonigMMachtensE. Mandibular involvement in chronic recurrent multifocal osteomyelitis (CRMO) in adulthood [in German]. Mund Kiefer Gesichtschir2000; 4: 187–92.
12.
DuffyCMLamPYDitchfieldMAllenRGrahamHK. Chronic recurrent multifocal osteomyelitis: Review of orthopaedic complications at maturity. J Pediatr Orthop2002; 22: 501–5.
13.
HuberAMLamPYDuffyCM. Chronic recurrent multifocal osteomyelitis: Clinical outcomes after more than five years of follow-up. J Pediatr2002; 141: 198–203.
14.
RobertsonLPHicklingP. Chronic recurrent multifocal osteomyelitis is a differential diagnosis of juvenile idiopathic arthritis. Ann Rheum Dis2001; 60: 828–31.
15.
TingleyRJadavjiTBoagGKieferGNTrevenenCCoppesMJ. Chronic recurrent multifocal osteomyelitis: A rare disorder presenting as multifocal bone lesions. Med Pediatr Oncol2001; 37: 132–7. [Erratum in Med Pediatr Oncol 2001;37: 487.]
16.
JurriaansESinghNPFinlayKFriedmanL. Imaging of chronic recurrent multifocal osteomyelitis. Radiol Clin North Am2001; 39: 305–27.
17.
PelkonenPRyoppySJaaskelainenJRapolaJRepoHKaitilaI. Chronic osteomyelitislike disease with negative bacterial cultures. Am J Dis Child1988; 142: 1167–73.
18.
ZuluagaAFGalvisWJaimesFVesgaO. Lack of microbiological concordance between bone and non-bone specimens in chronic osteomyelitis: An observational study. BMC Infect Dis2002; 2: 8.
ProseNSFahrnerLJMillerCRLayfieldL. Pustular psoriasis with chronic recurrent multifocal osteomyelitis and spontaneous fractures. J Am Acad Dermatol1994; 31: 376–9.
21.
PallerASPachmanLRichKEsterlyNBGonzalez-CrussiF. Pustulosis palmaris et plantaris: Its association with chronic recurrent multifocal osteomyelitis. J Am Acad Dermatol1985; 12: 927–30.
22.
KahnMFChamotAM. SAPHO syndrome. Rheum Dis Clin North Am1992; 18: 225–46.
