Pharyngeal Pressure Analysis by the Finite Element Method during Liquid Bolus Swallow

Abstract

The human pharynx is unique, acting as a complex interchange between the oral cavity and the esophagus, and between the nasal cavity and the lungs. It is actively involved in the transport of food and liquid, producing the forces that guide the bolus into the upper esophagus and away from the adjacent larynx and lungs. This study developed a biomechanical computer model of the human pharynx, utilizing a finite element method (FEM). Control 2-dimensional cine computed tomography images were obtained during 10-mL barium paste swallows at 8 levels extending from the tongue base to the cricopharyngeal level in order to encompass the entire pharynx. Three-dimensional finite element models of the pharynx were reconstructed from the geometric information obtained from the images at each level. Using an inverse dynamic approach with the addition of known tissue properties, we analyzed the 8 models under estimated pressure histories during swallow. Within each model, changes in the cross-sectional intraluminal area were calculated and compared with the area from the computer-generated FEM model. Area matching allowed estimation of intraluminal pressure gradients during swallow. The estimated pressure gradients were distributed through a range from 10 to 55 mm Hg, varying from one region to another and showing different patterns for the upper 4 levels and the lower 4 levels. The contraction velocity for the upper 4 levels was much higher than that for the lower 4 levels. The higher contraction velocities and pressure gradients in the upper levels are consistent with the bolus velocities required for efficient swallow.