Prognostic Value of the Triglycerides-glucose Index for Major Adverse Cardiac Events in Severe Aortic Stenosis Patients After TAVI

Abstract

The present study aimed to evaluate whether the Triglycerides-Glucose (TyG) index has a prognostic value for major adverse cardiac events (MACEs), including stroke, necessity of pacemaker, acute kidney failure, and short-term all-cause mortality at 12 months, in aortic stenosis (AS) patients who underwent transcatheter aortic valve implantation (TAVI). A total of 380 patients who underwent TAVI due to severe AS were retrospectively included in the study. The main outcome of the study was MACEs at 12 months. The TyG index was found to be higher in TAVI patients who developed MACEs than in those who did not develop them. Multivariate Cox regression analysis revealed that TyG (P < .001) was an independent predictor of MACEs in AS patients after TAVI. A TyG index value of >4.77 following TAVI had 50% sensitivity and 50% specificity (AUC [area under the curve]: 0.694, P < .001) for MACEs. This is the first study to show that a high pre-procedural TyG index has a predictive value for MACEs in AS patients undergoing TAVI.