We investigated the effect of sex and age on the association between serum creatinine/cystatin C (CCR) ratio and carotid plaque in patients with type 2 diabetes mellitus (T2DM). The carotid plaque group and the non-plaque group were divided according to cervical vascular ultrasound; the general and biochemical data of the two groups were compared according to CCR, gender, and age. Binary logistic regression was used to analyze the factors influencing carotid plaque. A total of 1429 patients with T2DM were included in this study. On multivariate analysis, CCR was an independent predictor of carotid plaque with an adjusted odds ratio (OR) of 1.681 [1.250–2.260]. The risk of carotid plaque in men with T2DM increased significantly (P < .05) with decreasing levels of CCR. In addition, an association between CCR and carotid plaque was found in individuals with T2DM <65 years of age (P < .05). CCR is strongly associated with the risk of carotid plaques in persons with T2DM and are an independent risk factor for carotid plaques in men and people aged <65 years with T2DM.
AmerDA. Classification and diagnosis of diabetes: standards of medical care in diabetes-2020. Diabetes Care. 2020;43:S14-S31.
2.
SongPFangZWangHCaiYRahimiK. Global and regional prevalence, burden, and risk factors for carotid atherosclerosis: a systematic review, meta-analysis, and modelling study. Lancet Global Health. 2020;8:E721-E729.
3.
SongPXiaWZhuYWangMChangX. Prevalence of carotid atherosclerosis and carotid plaque in Chinese adults: a systematic review and meta-regression analysis. Atherosclerosis. 2018;276:67-73.
4.
OoiYCGonzalezNR. Management of extracranial carotid artery disease. Cardiol Clin. 2015;33:1-35.
5.
MosenzonOChengAYYRabinsteinAASaccoS. Diabetes and stroke: what are the connections?Journal of Stroke. 2023;25:26-38.
6.
KashaniKRosnerMHOstermannM. Creatinine: from physiology to clinical application. Eur J Intern Med. 2020;72:9-14.
7.
Herget-RosenthalSTraboldSHuesingJHeemannUPhilippTKribbenA. Cystatin C - an accurate marker of glomerular filtration rate after renal transplantation?Transpl Int. 2000;13:285-289.
8.
KashaniKBFrazeeENKukralovaLSarvottamKHerasevichVYoungPM. Evaluating muscle mass by using markers of kidney function: development of the sarcopenia index. Crit Care Med. 2017;45:e23-e29.
9.
BarretoEFKanderiTDiCeccoSRLopez-RuizAPoyantJO. Sarcopenia index is a simple objective screening tool for malnutrition in the critically ill. J Parenter Enteral Nutr. 2019;43:780-788.
10.
ZhengWHZhuYBYaoYHuangHB. Serum creatinine/cystatin C ratio as a muscle mass evaluating tool and prognostic indicator for hospitalized patients: a meta-analysis. Front Med. 2023;9:1058464.
11.
Cruz-JentoftAJBahatGBauerJBoirieY. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48:16-31.
12.
QiuSCaiXXieBYuanY. Normalized creatinine-to-cystatin C ratio and risk of diabetes in middle-aged and older adults: the China health and retirement longitudinal study. Diabetes & Metabolism Journal. 2022;46:476-485.
13.
FengLGaoQHuK, et al.Prevalence and risk factors of sarcopenia in patients with diabetes: a meta-analysis. J Clin Endocrinol Metabol. 2022;107:1470-1483.
14.
HeNZhangYZhangLZhangSYeH. Relationship between sarcopenia and cardiovascular diseases in the elderly: an overview. Frontiers in Cardiovascular Medicine. 2021;8:743710.
15.
SeoDHLeeYHSuhYJ, et al.Low muscle mass is associated with carotid atherosclerosis in patients with type 2 diabetes. Atherosclerosis. 2020;305:19-25.
16.
TakahashiFHashimotoYKajiASakaiROkamuraTKitagawaN. Sarcopenia is associated with a risk of mortality in people with type 2 diabetes mellitus. Front Endocrinol. 2021;12:783363.
17.
ShinJY. Low serum creatinine to cystatin C ratio is independently associated with sarcopenia and high carotid plaque score in patients with type 2 diabetes. Nutrition Metabolism and CardiovascularDiseases. 2022;32:1454-1462.
18.
NakanishiSIwamotoMShinoharaHIwamotoH. Impact of sarcopenia on glycemic control and atherosclerosis in Japanese patients with type 2 diabetes: cross-sectional study using outpatient clinical data. Geriatr Gerontol Int. 2020;20:1196-1201.
19.
SakaiYLehmanVTEisenmengerLB, et al. Vessel wall MR imaging of aortic arch, cervical carotid and intracranial arteries in patients with embolic stroke of undetermined source: a narrative review. Front Neurol. 2022;13:968390.
20.
Chinese Medical Association Diabetes Branch. Chinese Guidelines for the prevention and control of type 2 diabetes mellitus (2020 edition). Chinese Journal of Diabetes. 2021;13:315-409.
21.
ShanshanSHongzhenLYuanyuanY. Consensus opinion on early screening and surveillance for people at high risk of pancreatic cancer in China (2021, nanjing). Journal of Clinical Hepatobiliary Disease. 2022;38:1016-1022.
22.
LeveyASStevensLASchmidCH, et al.A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604-612.
23.
NymanEVanoliDNaslundUGronlundC. Inter-sonographer reproducibility of carotid ultrasound plaque detection using Mannheim consensus in subclinical atherosclerosis. Clin Physiol Funct Imag. 2020;40:46-51.
24.
MiyakeHKanazawaITanakaKSugimotoT. Low skeletal muscle mass is associated with the risk of all-cause mortality in patients with type 2 diabetes mellitus. Therapeutic Advances in Endocrinology and Metabolism. 2019;10:2042018819842971.
25.
WeiWLiSLiuJ, et al. Prognostic value of creatinine-to-cystatin c ratio in patients with type 2 diabetes mellitus: a cohort study. Diabetol Metab Syndrome. 2022;14:176.
26.
GuilletCBoirieY. Insulin resistance: a contributing factor to age-related muscle mass loss?Diabetes Metabol. 2005;31:5S20-5S26.
27.
El AssarMAlvarez-BustosASosaPAnguloJRodriguez-ManasL. Effect of physical activity/exercise on oxidative stress and inflammation in muscle and vascular aging. Int J Mol Sci. 2022;23:8713.
28.
JungCYJooYSKimHW, et al.Creatinine-cystatin C ratio and mortality in patients Receiving intensive care and continuous kidney replacement therapy: a retrospective cohort study. Am J Kidney Dis. 2021;77:509.
29.
OchiMKoharaKTabaraY, et al.Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men. Atherosclerosis. 2010;212:327-332.
30.
KoharaK. Transdisciplinary approach for sarcopenia. Sarcopenia and atherosclerosis. Clin Calcium. 2014;24:1487-1492.
31.
JanssenIHeymsfieldSBWangZMRossR. Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. J Appl Physiol. 2000;89:81-88.
32.
HeoJEKimHCShimJ-S, et al.Association of appendicular skeletal muscle mass with carotid intima-media thickness according to body mass index in Korean adults. Epidemiology and Health. 2018;40.
33.
Srinivas-ShankarUWuFCW. Frailty and muscle function: role for testosterone? In: JonesTH, ed. Advances in the Management of Testosterone Deficiency. 2009:133-149.
34.
LiuYGaoJHaiRZhaoXRNaRS. Relationship between sarcopenia and atherosclerosis in the elderly. J Am Geriatr Soc. 2019;67:S609-S610.
35.
Sousa-CoelhoABotelhoMGuerreiroCPaisS. Correlation between sarcopenia and atherosclerosis/cardiovascular risk factors in the elderly. Eur J Publ Health. 2020;30:1101-1262.
36.
EhrlichJRKaluznyMBaumannSLehmannRHohnloserSH. Biomarkers of structural remodelling and endothelial dysfunction for prediction of cardiovascular events or death in patients with atrial fibrillation. Clin Res Cardiol. 2011;100:1029-1036.
37.
RongY-DBianA-LHuH-YMaYZhouX-Z. Study on relationship between elderly sarcopenia and inflammatory cytokine IL-6, anti-inflammatory cytokine IL-10. BMC Geriatr. 2018;18:308.
38.
WangTT. Searching for the link between inflammaging and sarcopenia. Ageing Res Rev. 2022;77:101611.
39.
Luevano-ContrerasCGaray-SevillaMEWrobelKMalacaraJMWrobelK. Dietary advanced glycation end products restriction diminishes inflammation markers and oxidative stress in patients with type 2 diabetes mellitus. J Clin Biochem Nutr. 2013;52:22-26.
40.
MiyabeMOhashiKShibataR, et al.Muscle-derived follistatin-like 1 functions to reduce neointimal formation after vascular injury. Cardiovasc Res. 2014;103:111-120.
41.
ParkC-HDoJGLeeY-TYoonKJ. Sex difference in cutoff and prevalence of sarcopenia among 300,090 Urban Korean population: association with metabolic syndrome. Medicina-Lithuania. 2022;58:101611.
42.
LeePCLeeKCYangTC, et al. Sarcopenia-related gut microbial changes are associated with the risk of complications in people with cirrhosis. Jhep Reports. 2023;5:100619.
43.
SayerAASyddallHMartinHPatelHBaylisDCooperC. The developmental origins of sarcopenia. J Nutr Health Aging. 2008;12:427-432.
44.
JungHNJungCHHwangY-C. Sarcopenia in youth. Metab, Clin Exp. 2023;144:155557.
45.
AlcazarJRodriguez-LopezCDelecluseCThomisMVan RoieE. Ten-year longitudinal changes in muscle power, force, and velocity in young, middle-aged, and older adults. Journal of Cachexia Sarcopenia and Muscle. 2023;14:1019-1032.
46.
Petermann-RochaFGraySRPellJPHoFKCelis-MoralesC. The joint association of sarcopenia and frailty with incidence and mortality health outcomes: a prospective study. Clin Nutr. 2021;40:2427-2434.
47.
HanPKangLGuoQ, et al.Prevalence and factors associated with sarcopenia in suburb-dwelling older Chinese using the Asian working group for sarcopenia definition. Journals of Gerontology Series a-Biological Sciences and Medical Sciences. 2016;71:529-535.
48.
PoznyakAVSadykhovNKKartuesovAG, et al. Hypertension as a risk factor for atherosclerosis: cardiovascular risk assessment. Frontiers in Cardiovascular Medicine. 2022;9:959285.
49.
Hernandez-LepeMAMiranda-GilMIValbuena-GregorioEOlivas-AguirreFJ. Exercise Programs combined with diet supplementation improve body composition and physical function in older adults with sarcopenia: a systematic review. Nutrients. 2023;15:1998.
50.
SayerAAStewartCPatelHCooperC. The developmental origins of sarcopenia: from epidemiological evidence to underlying mechanisms. Journal of Developmental Origins of Health and Disease. 2010;1:150-157.
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