Predictive Value of Admission Platelet Volume Indices for In-hospital Major Adverse Cardiovascular Events in Acute ST-Segment Elevation Myocardial Infarction
Restricted accessResearch articleFirst published online February, 2015
Predictive Value of Admission Platelet Volume Indices for In-hospital Major Adverse Cardiovascular Events in Acute ST-Segment Elevation Myocardial Infarction
Although mean platelet volume (MPV) is an independent correlate of impaired angiographic reperfusion and 6-month mortality in ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI), there is less data regarding the association between platelet distribution width (PDW) and in-hospital major adverse cardiovascular events (MACEs). A total of 306 patients with STEMI pPCI were evaluated. No reflow was defined as a post-PCI thrombolysis in myocardial infarction (TIMI) flow grade of 0, 1, or 2 (group 1). Angiographic success was defined as TIMI flow grade 3 (group 2). The values of MPV and PDW were higher among patients with no reflow. In-stent thrombosis, nonfatal myocardial infarction, in-hospital mortality, and MACEs were significantly more frequent among patients with no reflow. In multivariate analysis, PDW, MPV, high-sensitivity C-reactive protein, and glucose on admission were independent correlates of in-hospital MACEs. Admission PDW and MPV are independent correlates of no reflow and in-hospital MACEs among patients with STEMI undergoing pPCI.
GalassoGSchiekoferSD’AnnaC. No-reflow phenomenon: pathophysiology, diagnosis, prevention, and treatment. a review of the current literature and future perspectives. Angiology. 2014;65(3):180–189. doi: 10.1177/0003319712474336.
2.
SchwartzBGKlonerRA. Coronary no reflow. J Mol Cell Cardiol. 2012;52(4):873–882.
3.
ButlerMJChanWTaylorAJDartAMDuffySJ. Management of the no-reflow phenomenon. Pharmacol Ther. 2011;132(1):72–85.
4.
TIMI Study Group. The thrombolysis in myocardial infarction (TIMI) trial. phase I findings. N Engl J Med. 1985;312(14):932–936.
5.
KayaMGUyarelHAkpekM. Prognostic value of uric acid in patients with ST-elevated myocardial infarction undergoing primary coronary intervention. Am J Cardiol. 2012;109(4):486–491.
6.
AkpekMKayaMGLamYY. Relation of neutrophil/lymphocyte ratio to coronary flow to in-hospital major adverse cardiac events in patients with ST-elevated myocardial infarction undergoing primary coronary intervention. Am J Cardiol. 2012;110(5):621–627.
7.
ItoH. No-reflow phenomenon and prognosis in patients with acute myocardial infarction. Nat Clin Pract Cardiovasc Med. 2006;3(9):499–506.
8.
GibsonCMMurphySARizzoMJ. Relationship between TIMI frame count and clinical outcomes following thrombolytic administration. thrombolysis in myocardial infarction (TIMI) study group. Circulation. 1999;99(15):1945–1950.
9.
MehtaRHHarjaiKJBouraJ. Prognostic significance of transient no-reflow during primary percutaneous coronary intervention for ST-elevation acute myocardial infarction. Am J Cardiol. 2003;92(12):1445–1447.
10.
EnglerRL. Free radical and granulocyte-mediated injury during myocardial ischemia and reperfusion. Am J Cardiol. 1989;63(10):19E–23E.
11.
KayaMGAkpekMLamYY. Prognostic value of neutrophil/lymphocyte ratio in patients with ST-elevated myocardial infarction undergoing primary coronary intervention: a prospective, multicenter study. Int J Cardiol. 2013;168(2):1154–1159.
12.
AkpekMElcikDKalayN. The prognostic value of serum gamma glutamyl transferase activity on admission in patients with STEMI undergoing primary PCI. Angiology. 2012;63(8):579–585.
13.
DreyerWJMichaelLHWestMS. Neutrophil accumulation in ischemic canine myocardium. Insights into time course, distribution, and mechanism of localization during early reperfusion. Circulation. 1991;84(1):400–411.
14.
HuczekZKochmanJFilipiakKJ. Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. J Am Coll Cardiol. 2005;46(2):284–290.
15.
ReffelmannTKlonerRA. The no-reflow phenomenon: A basic mechanism of myocardial ischemia and reperfusion. Basic Res Cardiol. 2006;101(5):359–372.
16.
MartinJFPlumbJKilbeyRSKishkYT. Changes in volume and density of platelets in myocardial infarction. Br Med J. 1983;287(6390):456–459.
17.
MartinJFTrowbridgeEASalmonGPlumbJ. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res. 1983;32(5):443–460.
18.
ThompsonCBJakubowskiJAQuinnPGDeykinDValeriCR. Platelet size as a determinant of platelet function. J Lab Clin Med. 1983;101(2):205–213.
19.
GilesHSmithREMartinJF. Platelet glycoprotein IIb-IIIa and size are increased in acute myocardial infarction. Eur J Clin Invest. 1994;24(1):69–72.
20.
JagroopIAMikhailidisDP. The effect of tirofiban on fibrinogen/agonist-induced platelet shape change and aggregation. Clin Appl Thromb Hemost. 2008;14(3):295–302.
21.
CameronHAPhillipsRIbbotsonRMCarsonPH. Platelet size in myocardial infarction. Br Med J. 1983;287(6390):449–451.
22.
AkpekMKayaMGUyarelH. The association of serum uric acid levels on coronary flow in patients with STEMI undergoing primary PCI. Atherosclerosis. 2011;219(1):334–341.
23.
YaşarASBilenEYükselIO. Association between admission mean platelet volume and coronary patency after thrombolytic therapy for acute myocardial infarction. Turk Kardiyol Dern Ars. 2010;38(2):85–89.
24.
Estévez-LoureiroRSalgado-FernándezJMarzoa-RivasR. Mean platelet volume predicts patency of the infarct-related artery before mechanical reperfusion and short-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Thromb Res. 2009;124(5):536–540.
25.
AvramakisGPapadimitrakiEPapakonstandinouD. Platelets and white blood cell subpopulations among patients with myocardial infarction and unstable angina. Platelets. 2007;18(1):16–23.
26.
MadenOKacmazFSelcukH. Relationship of admission hematological indexes with myocardial reperfusion abnormalities in acute ST segment elevation myocardial infarction patients treated with primary percutaneous coronary interventions. Can J Cardiol. 2009;25(6):e164–e168.
27.
GasparyanAYAyvazyanLMikhailidisDPKitasGD. Mean platelet volume: a link between thrombosis and inflammation?Curr Pharm Des. 2011;17(1):47–58.
28.
BoosCJBeeversGDLipGY. Assessment of platelet activation indices using the ADVIATM 120 amongst ‘high-risk’ patients with hypertension. Ann Med. 2007;39(1):72–78.
29.
Van CottEMFletcherSRKratzA. Effects of the blood-collection tube material and long-term storage on platelet activation parameters on the ADVIA 120/2120 hematology system. Lab Hematol. 2005;11(1):71–75.
30.
VagdatliEGounariELazaridouEKatsibourliaETsikopoulouFLabrianouI. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14(1):28–32.
31.
AkpekMKayaMGYarliogluesM. Relationship between platelet indices and spontaneous echo contrast in patients with mitral stenosis. Eur J Echocardiogr. 2011;12(11):865–870.
32.
De LucaGVenegoniLIorioS. Platelet distribution width and the extent of coronary artery disease: results from a large prospective study. Platelets. 2010;21(7):508–514.
33.
BoosCJBalakrishnanBLipGY. The effects of coronary artery disease severity on time-dependent changes in platelet activation indices in stored whole blood. J Thromb Thrombolysis. 2008;25(2):135–140.
34.
GreiseneggerSEndlerGHsiehKTentschertSMannhalterCLalouschekW. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events?Stroke. 2004;35(7):1688–1691.
