Single nucleotide polymorphisms of angiotensin-converting enzyme (ACE) such as rs1799752, nuclear factor kappa B (NFkB) such as rs28362491 and cholesteryl ester transport protein (CETP) such as rs708272 (TaqB1) and rs5882 (I405V) were evaluated in nonagenarians, centenarians, and average life span individuals (controls). The study population (n = 307; 190 nonagenarians, 12 centenarians and 105 middle-aged controls) was genotyped for ACE, NFkB, and CETP genetic variants. The age of nonagenarian and centenarian group ranged between 90 and 111 years; centenarians and controls age ranged from 99 to 111, and from 18 to 80 years, respectively. The I carriers of ACE I/D gene were fewer in nonagenarians compared to centenarians (37.6% vs 62.5%, P = .016). The I carriers of ACE gene were more frequent in centenarians compared to controls (62% vs 41%, P = .045). No differences in frequency of common NFkB and CETP genotypes between patients with exceptional longevity and middle-aged patients were observed.
OeppenJVaupelJW. Demography. Broken limits to life expectancy. Science. 2002;296(5570):1029–1031.
2.
ParkSK. Genomic approaches for the understanding of aging in model organisms. BMB Rep. 2011;44(5):291–297.
3.
vB HjelmborgJIachineISkyttheA. Genetic influence on human lifespan and longevity. Hum Genet. 2006;119(3):312–321.
4.
FranceschiCOlivieriFMarchegianiF. Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech Ageing Dev. 2005;126(2):351–361.
5.
KirkwoodTB. A systematic look at an old problem. Nature. 2008;451(7179):644–647.
6.
BarzilaiNShuldinerAR. Searching for human longevity genes: The future history of gerontology in the post-genomic era. J Gerontol A Biol Sci Med Sci. 2001;56(2):M83–M87.
7.
TsaiMYLiNSharrettAR. Associations of genetic variants in ATP-binding cassette A1 and cholesteryl ester transfer protein and differences in lipoprotein subclasses in the multi-ethnic study of atherosclerosis. Clin Chem. 2009;55(3):481–488.
8.
KolovouGDAnagnostopoulouKKDaskalopoulouSSMikhailidisDPCokkinosDV. Clinical relevance of postprandial lipemia. Curr Med Chem. 2005;12(17):1931–1945.
9.
OrdovasJMCupplesLACorellaD. Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study. Arterioscler Thromb Vasc Biol. 2000;20(5):1323–1329.
10.
MitchWEPriceSR. Transcription factors and muscle cachexia: is there a therapeutic target?Lancet. 2001;357(9258):734–735.
11.
LeeMYWangY, Vanhoutte PM Senescence of cultured porcine coronary arterial endothelial cells is associated with accelerated oxidative stress and activation of NFkB. J Vasc Res. 2010;47(4):287–298.
GlasJTörökHPTonenchiL. Role of the NFKB1-94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes. Inflamm Bowel Dis. 2006;12(7):606–611.
16.
RigatBHubertCCorvolPSoubrierF. PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidylcarboxypeptidase 1). Nucleic Acids Res. 1992;20(6):1433.
17.
GudnasonVKakkoSNicaudV. Cholesteryl ester transfer protein gene effect on CETP activity and plasma high-density lipoprotein in European populations. The EARS Group. Eur J Clin Invest. 1999;29(2):116–128.
18.
KolovouGKolovouVVasiliadisIWierzbickiASMikhailidisDP. Ideal lipid profile and genes for an extended life span. Curr Opin Cardiol. 2011;26(4):348–355.
19.
ContiSCassisPBenigniA. Aging and the renin-angiotensin system. Hypertension. 2012;60(4):878–883.
20.
CalabreseVCorneliusCDinkova-KostovaAT. Cellular stress responses, hermetic phytochemicals and vitagenes in aging and longevity. Biochim Biophys Acta. 2012;1822(5):753–783.
21.
KolovouGStamatelatouMAnagnostopoulouK. Cholesteryl ester transfer protein gene polymorphisms and longevity syndrome. Open Cardiovasc Med J. 2010;4:14–19.
22.
FreemanDJSamaniNJWilsonV. A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland coronary prevention study. Eur Heart J. 2003;24(20):1833–1842
23.
KolovouGDAnagnostopoulouKKSalpeaKD. Postprandial lipemia in postmenopausal women with high fasting high-density lipoprotein cholesterol. Am J Med Sci. 2006;331(1):10–16.
24.
KolovouGDMikhailidisDPNordestgaardBGBilianouHPanotopoulosG. Definition of postprandial lipaemia. Curr Vasc Pharmacol. 2011;9(3):292–301.
25.
KolovouGDMikhailidisDPKovarJ. Assessment and clinical relevance of non-fasting and postprandial triglycerides: an expert panel statement. Curr Vasc Pharmacol. 2011;9(3):258–270.
26.
MihasCKolovouGDMikhailidisDP. Diagnostic value of postprandial triglyceride testing in healthy subjects: a meta-analysis. Curr Vasc Pharmacol. 2011;9(3):271-280
27.
BarzilaiNAtzmonGSchechterC. Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA. 2003;290(15):2030–2040
28.
SoerensenMDatoSTanQ. Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity[published online January 12, 2012]. Age (Dordr). 2012.
29.
CelliniENacmiasBOlivieriF. Cholesteryl ester transfer protein (CETP) I405 V polymorphism and longevity in Italian centenarians. Mech Ageing Dev. 2005;126(6-7):826–828.
30.
NovelliVViviani AnselmiCRoncaratiR. Lack of replication of genetic associations with human longevity. Biogerontology. 2008;9(2):85–92.
31.
HeleniusMHanninenMLehtinenSKSalminenA. Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B. Biochem J. 1996;318(Pt 2):603–608.
32.
KorhonenPHeleniusMSalminenA. Age-related changes in the regulation of transcription factor NFkappa B in rat brain. Neurosci Lett. 1997;225(1):61–64.
33.
AdlerASSinhaSKawaharaTLZhangJYSegalEChangHY. Motif module map reveals enforcement of aging by continual NFκB activity. Genes Dev. 2007;21(24):3244–3257.
34.
BernardDGosselinKMonteD. Involvement of Rel/nuclear factor-kappaB transcription factors in keratinocyte senescence. Cancer Res. 2004;64(2):472–481.
35.
WangXLuPXuL. Updated meta-analysis of NFkappaB1 -94ins/Delattg promoter polymorphism and cancer risk based on 19 case-control studies. Asian Pac J Cancer Prev. 2011;12(10):2479–2484.
36.
SchachterFFaure-DelanefLGuenotF. Genetic associations with human longevity at the APOE and ACE loci. Nat Genet. 1994;6(1):29–32.
37.
GalinskyDTysoeCBrayneCE. Analysis of the apo E/apo C-I, angiotensin-converting enzyme and methylenetetrahydrofolatereductase genes as candidates affecting human longevity. Atherosclerosis. 1997;129(2):177–183.
38.
SeripaDFranceschiMMateraMG. Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy. J Gerontol A BiolSci Med Sci. 2006;61(9):918–923.
39.
ZajcPetranovićMSkarić-JurićTSmolejNarančićN. Angiotensin-converting enzyme deletion allele is beneficial for the longevity of Europeans. Age (Dordr). 2012;34(3):583–595.
40.
Fiuza-LucesCRuizJRRodríguez-RomoG. Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort. J Renin Angiotensin Aldosterone Syst. 2011;12(3):202–207.
41.
YangJKGongYYXieL. Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population. J Renin Angiotensin Aldosterone Syst. 2009;10(2):115–118.
42.
BlanchéHCabanneLSahbatouMThomasG. A study of French centenarians: are ACE and APOE associated with longevity?C R Acad Sci III. 2001;324(2):129–135.
43.
ChoiYHKimJHKimDK. Distributions of ACE and APOE polymorphisms and their relations with dementia status in Korean centenarians. J Gerontol A Biol Sci Med Sci. 2003;58(3):227–231.
44.
CambienFPoirierOLecerfL. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature.1992;359(6396):641–644.
45.
ChangSNLinJWJuangJMTsaiCTHwangJJChiangFT. Association between genetic polymorphisms in the renin-angiotensin system and systolic heart failure revised by a propensity score-based analysis. Cardiology. 2010;116(4):279–285.
46.
AbcheeAEl-SibaiMYouhannaS. The I allele of the angiotensin converting enzyme I/D polymorphism confers protection against coronary artery disease. Coron Artery Dis. 2010;21(3):151–156.
47.
YangJKGongYYXieL. Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population. J Renin Angiotensin Aldosterone Syst. 2009;10(2):115–118.
48.
BlanchéHCabanneLSahbatouMThomasG. A study of French centenarians: are ACE and APOE associated with longevity?C R Acad Sci III. 2001;324(2):129–135.
49.
VinaJGambiniJLopez-GruesoRAbdelazizKMJoveMBorrasC. Females live longer than males: role of oxidative stress. Curr Pharm Des. 2011;17(36):3959–3965.
50.
WheelerHEKimSK. Genetics and genomics of human ageing. Philos Trans R Soc Lond B Biol Sci. 2011;366(1561):43–50.
51.
SlagboomPEBeekmanMPasstoorsWM. Genomics of human longevity. Philos Trans R Soc Lond B Biol Sci. 2011;366(1561):35–42.
52.
McDermottRGillespieSMNelsonDNewmanCShahMN.Characteristics and acute care use patterns of patients in a senior living community medical practice. J Am Med Dir Assoc. 2012;13(3):260–263.
