Resting Muscle Oxygen Consumption by Near-Infrared Spectroscopy in Peripheral Arterial Disease: A Parameter to be Considered in a Clinical Setting?

Abstract

Resting muscle VO₂ consumption (rmVO₂) as measured by near-infrared spectroscopy (NIRS) has been poorly studied in peripheral arterial disease (PAD). We studied the feasibility of its assessment in a clinical setting, compared values from PAD and healthy participants, and identified factors affecting rmVO₂ in PAD. A total of 119 PAD patients with claudication and 30 healthy participants were enrolled. Ankle brachial index (ABI), adipose tissue thickness, and rmVO₂ in the gastrocnemius after venous (rmVO₂ven) or arterial (rmVO₂art) occlusion were measured with NIRS. Compared to rmVO₂art, rmVO₂ven determination was less painful (P = .001), with higher values (P < .0001). rmVO₂ven of PAD patients was not significantly different from healthy participants and was inversely correlated with the corresponding ABI (P = .018). rmVO₂ven from severely diseased legs was higher than values from borderline/moderately diseased legs (P = .003). The determination of rmVO₂ven by NIRS is suitable for the clinical setting and allows noninvasive quantification of a compensatory peripheral adaptation in patients with PAD.

Keywords

intermittent claudication muscle metabolism noninvasive near-infrared spectroscopy peripheral vascular disease

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