Fast-Track Score to Predict the Feasibility of Early Extubation Post Liver Transplant

Abstract

Background

Over the past several years, the liver transplant community has embraced the concept of fast-tracking patients to facilitate earlier postoperative recovery.

Aim

Derive and validate a novel “fast-track” risk score that captures the demographic and clinical characteristics of DDLT patients to predict the likelihood of early extubation after surgery.

Design

Adult patients who underwent non-fulminant DDLT between January 2014 and July 2019 were included. The cohort was divided in 2 groups: patients extubated within 4 hours of surgery vs extubated after 4 h. Logistic regression was performed to identify the independent predictors of early extubation. The area under the curve (AUC) was calculated to measure the ability of the risk score to predict early extubation. The score was validated by applying coefficients of the regression model to the validation cohort and calculating the AUC.

Results

A total of 290 DDLT patients were included, of which 175 (60%) were in the “delayed extubation” group and 115 (40%) were in the “fast-track” group. Patients with a MELD <29, transfused <4 units of pRBCs, and transfused <5 units of FFP during surgery were 2.30 times, 5.74 times, and 3.09 times more likely to be extubated early, respectively. A risk score with an integer point scale was derived and exhibited an AUC of .80. The proportion of patients who were extubated early increased from 2.78% at a score of 0 to 66.67% at a score of 4.

Conclusions

The proposed score provides a fast and easy method to help identify DDLT patients suitable for early extubation.