Abstract
Science is often considered the best available route to knowledge and, thus, essential for societal progress. Yet contemporary science faces several challenges. These challenges include politicization, misinformation, and inequalities. I outline each of these threats, detailing the ways in which they can undermine the optimal production and application of science. I provide an overview of various research agendas on each, as covered in this volume. Without minimizing the seriousness posed by each threat, I also suggest that existing work provides reason for hope that the scientific enterprise can address these challenges and continue to improve societal well-being.
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