The acute and chronic effects of traumatic brain injury (TBI) have been widely described; however, there is limited knowledge on how a TBI sustained during early adulthood or mid-adulthood will influence aging. Epidemiological studies have explored whether TBI poses a risk for dementia and other neurodegenerative diseases associated with aging. We will discuss the influence of TBI and resulting medical comorbidities such as endocrine, sleep, and inflammatory disturbances on age-related gray and white matter changes and cognitive decline. Post mortem studies examining amyloid, tau, and other proteins will be discussed within the context of neurodegenerative diseases and chronic traumatic encephalopathy. The data support the suggestion that pathological changes triggered by an earlier TBI will have an influence on normal aging processes and will interact with neurodegenerative disease processes rather than the development of a specific disease, such as Alzheimer's or Parkinson's. Chronic neurophysiologic change after TBI may have detrimental effects on neurodegenerative disease.
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References
1.
SelassieA.W., ZaloshnjaE., LangloisJ.A., MillerT., JonesP., and SteinerC. (2008). Incidence of long-term disability following traumatic brain injury hospitalization, United States, 2003. J. Head Trauma Rehabil., 23, 123–131.
2.
AraniA., MurphyM.C., GlaserK.J., ManducaA., LakeD.S., KruseS.A., JackC.R.Jr., EhmanR.L., and HustonJ. 3rd. (2015). Measuring the effects of aging and sex on regional brain stiffness with MR elastography in healthy older adults. Neuroimage, 111, 59–64.
3.
MaxwellW.L., MacKinnonM.A., StewartJ.E., and GrahamD.I. (2010). Stereology of cerebral cortex after traumatic brain injury matched to the Glasgow outcome score. Brain, 133, 139–160.
4.
TurkheimerE., CullumC.M., HublerD.W., PaverS.W., YeoR.A., and BiglerE.D. (1984). Quantifying cortical atrophy. J. Neurol. Neurosurg. Psychiatry, 47, 1314–1318.
5.
MassmanP.J., BiglerE.D., CullumC.M., and NaugleR.I. (1986). The relationship between cortical atrophy and ventricular volume. Int. J. Neurosci., 30, 87–99.
6.
ShookB.A., LenningtonJ.B., AcabchukR.L., HallingM., SunY., PetersJ., WuQ., MahajanA., FellowsD.W., and ConoverJ.C. (2014). Ventriculomegaly associated with ependymal gliosis and declines in barrier integrity in the aging human and mouse brain. Aging Cell. 13, 340–350.
7.
LevinH.S., WilliamsD.H., ValastroM., EisenbergH.M., CroffordM.J., and HandelS.F. (1990). Corpus callosal atrophy following closed head injury: detection with magnetic resonance imaging. J. Neurosurg., 73, 77–81.
8.
FranklinR.J., ZhaoC., and SimF.J. (2002). Ageing and CNS remyelination. Neuroreport, 13, 923–928.
9.
ZieglerD.A., PiguetO., SalatD.H., PrinceK., ConnallyE., and CorkinS. (2010). Cognition in healthy aging is related to regional white matter integrity, but not cortical thickness. Neurobiol. Aging, 31, 1912–1926.
10.
KatzmanR. (2008). The prevalence and malignancy of Alzheimer disease: a major killer. Alzheimers Dement. 4, 378–380.
11.
HaradaC.N., Natelson LoveM.C., and TriebelK.L. (2013). Normal cognitive aging. Clin. Geriatr. Med., 29, 737–752.
12.
SatzP. (1993). Brain reserve capacity on symptom onset after brain injury: a formulation and review of evidence for the threshold theory. Neuropsychology, 7, 273–295.
13.
SternY. (2002). What is cognitive reserve? Theory and research application of the reserve concept. J. Int. Neuropsychol. Soc., 8, 448–460.
14.
RushtonJ.P. and AnkneyC.D. (2009). Whole brain size and general mental ability: a review. Int. J. Neurosci., 119, 691–731.
15.
MacLullichA.M., FergusonK.J., DearyI.J., SecklJ.R., StarrJ.M., and WardlawJ.M. (2002). Intracranial capacity and brain volumes are associated with cognition in healthy elderly men. Neurology, 59, 169–174.
16.
RoyleN.A., BoothT., Valdes HernandezM.C., PenkeL., MurrayC., GowA.J., ManiegaS.M., StarrJ., BastinM.E., DearyI.J., and WardlawJ.M. (2013). Estimated maximal and current brain volume predict cognitive ability in old age. Neurobiol Aging, 34, 2726–2733.
17.
FilippiM., van den HeuvelM.P., FornitoA., HeY., Hulshoff PolH.E., AgostaF., ComiG., and RoccaM.A. (2013). Assessment of system dysfunction in the brain through MRI-based connectomics. Lancet Neurol. 12, 1189–1199.
18.
MaasA.I. and MenonD.K. (2012). Traumatic brain injury: rethinking ideas and approaches. Lancet Neurol. 11, 12–13.
19.
SchiffN.D. (2006). Measurements and models of cerebral function in the severely injured brain. J. Neurotrauma, 23, 1436–1449.
20.
Arenaza-UrquijoE.M., BoschB., Sala-LlonchR., Sole-PadullesC., JunqueC., Fernandez-EspejoD., BargalloN., RamiL., MolinuevoJ.L., and Bartres-FazD. (2011). Specific anatomic associations between white matter integrity and cognitive reserve in normal and cognitively impaired elders. Am. J. Geriatr. Psychiatry, 19, 33–42.
21.
CaeyenberghsK., LeemansA., LeunissenI., GooijersJ., MichielsK., SunaertS., and SwinnenS.P. (2014). Altered structural networks and executive deficits in traumatic brain injury patients. Brain Struct. Funct., 219, 193–209.
22.
BlumbergM., HardyJ., and RobinsonS. (2009). Handbook of Developmental Neuroscience. Oxford: New York.
23.
PageS.J., GaterD.R., and BachY.R.P. (2004). Reconsidering the motor recovery plateau in stroke rehabilitation. Arch. Phys. Med. Rehabil., 85, 1377–1381.
24.
YuhE.L., CooperS.R., MukherjeeP., YueJ.K., LingsmaH.F., GordonW.A., ValadkaA.B., OkonkwoD.O., SchnyerD.M., VassarM.J., MaasA.I., and ManleyG.T.; Track-TBI Investigators. (2014). Diffusion tensor imaging for outcome prediction in mild traumatic brain injury: a TRACK-TBI study. J. Neurotrauma, 31, 1457–1477.
25.
SmithD.H., JohnsonV.E., and StewartW. (2013). Chronic neuropathologies of single and repetitive TBI: substrates of dementia?. Nat. Rev. Neurol., 9, 211–221.
26.
PlassmanB.L., HavlikR.J., SteffensD.C., HelmsM.J., NewmanT.N., DrosdickD., PhillipsC., GauB.A., Welsh-BohmerK.A., BurkeJ.R., GuralnikJ.M., and BreitnerJ.C. (2000). Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias. Neurology, 55, 1158–1166.
27.
BlatterD.D., BiglerE.D., GaleS.D., JohnsonS.C., AndersonC.V., BurnettB.M., ParkerN., KurthS., and HornS.D. (1995). Quantitative volumetric analysis of brain MR: normative database spanning 5 decades of life. A.J.N.R. Am. J. Neuroradiol., 16, 241–251.
28.
ChetelatG., VillemagneV.L., PikeK.E., BaronJ.C., BourgeatP., JonesG., FauxN.G., EllisK.A., SalvadoO., SzoekeC., MartinsR.N., AmesD., MastersC.L., and RoweC.C.; Australian Imaging Biomarkers and Lifestyle Study of Ageing (AIBL) Research Group. (2010). Larger temporal volume in elderly with high versus low beta-amyloid deposition. Brain, 133, 3349–3358.
29.
BiglerE.D., BlatterD.D., AndersonC.V., JohnsonS.C., GaleS.D., HopkinsR.O., and BurnettB. (1997). Hippocampal volume in normal aging and traumatic brain injury. A.J.N.R. Am J. Neuroradiol., 18, 11–23.
30.
WhitnallL., McMillanT.M., MurrayG.D., and TeasdaleG.M. (2006). Disability in young people and adults after head injury: 5–7 year follow up of a prospective cohort study. J. Neurol. Neurosurg. Psychiatry, 77, 640–645.
31.
GoldsteinG. and ShellyC.H. (1975). Similarities and differences between psychological deficit in aging and brain damage. J. Gerontol., 30, 448–455.
32.
AshmanT.A., CantorJ.B., GordonW.A., SacksA., SpielmanL., EganM., and HibbardM.R. (2008). A comparison of cognitive functioning in older adults with and without traumatic brain injury. J. Head Trauma Rehabil., 23, 139–148.
33.
VeldhuisJ.D., SharmaA., and RoelfsemaF. (2013). Age-dependent and gender-dependent regulation of hypothalamic-adrenocorticotropic-adrenal axis. Endocrinol. Metab. Clin. North Am., 42, 201–225.
34.
HogervorstE. (2013). Effects of gonadal hormones on cognitive behaviour in elderly men and women. J. Neuroendocrinol., 25, 1182–1195.
35.
KreberL.A., GriesnbachG.S., and AshleyJ.A. (2016). Detection of Growth Hormone Deficiency in adults with chronic traumatic brain injury. J. Neurotrauma, 33, 1607–1613.
36.
LiebermanS.A., OberoiA.L., GilkisonC.R., MaselB.E., and UrbanR.J. (2001). Prevalence of neuroendocrine dysfunction in patients recovering from traumatic brain injury. J. Clin. Endocrinol. Metab., 86, 2752–2756.
37.
McEwenB. and MilnerT.A. (2017). Understanding the broad influence of sex hormones and sex differences in the brain. J. Neurosci. Res., 95, 24–39.
38.
Slewa-YounanS., van den BergS., BaguleyI.J., NottM., and CameronI.D. (2008). Towards an understanding of sex differences in functional outcome following moderate to severe traumatic brain injury: a systematic review. J. Neurol. Neurosurg. Psychiatry, 79, 1197–1201.
39.
JonesC.M. and BoelartK. (2015). The endocrinology of ageing: a mini review. Gerontology, 61, 291–300.
40.
AshpoleN.M., SandersJ.E., HodgesE.L., YanH., and SonntagW.E. (2015). Growth hormone, insulin-like growth factor-1 and the aging brain. Exp. Gerontol., 68, 76–81.
41.
AbergD. (2010). Role of the growth hormone/insulin-like growth factor 1 axis in neurogenesis. Endocr. Dev., 17, 63–76.
42.
KumarS., PatelR., MooreS., CrawfordD.K., SuwannaN., MangiardiM., and Tiwari-WoodruffS.K. (2013). Estrogen receptor β ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis. Neurobiol. Dis., 56, 131–144.
43.
AshmanT.A., GordonW.A., CantorJ.B., and HibbardM.R. (2006). Neurobehavioral consequences of traumatic brain injury. Mt. Sinai J. Med., 73, 999–1005.
44.
HibbardM.R., UysalS., KeplerK., BogdanyJ., and SilverJ. (1998). Axis I psychopathology in individuals with traumatic brain injury. J. Head Trauma Rehabil., 13, 24–39.
45.
BryantR.A., MarosszekyJ.E., CrooksJ., and GurkaJ.A. (2000). Posttraumatic stress disorder after severe traumatic brain injury. Am. J. Psychiatry, 157, 629–631.
46.
DamaniM.R., ZhaoL., FontainhasA.M., AmaralJ., FarissR.N., and WongW.T. (2011). Age‐related alterations in the dynamic behavior of microglia. Aging Cell. 10, 263–276.
47.
JohnsonV.E., StewartJ.E., BegbieF.D., TrojanowskiJ.Q., SmithD.H., and StewartW. (2013). Inflammation and white matter degeneration persist for years after a single traumatic brain injury. Brain, 136, 28–42.
48.
SmithC., GentlemanS.M., LeclercqP.D., MurrayL.S., GriffinW.S., GrahamD.I., and NicollJ.A. (2013). The neuroinflammatory response in humans after traumatic brain injury. Neuropathol. Appl. Neurobiol., 39, 654–666.
49.
Nagamoto-CombsK., McNealD.W., MorecraftR.J., and CombsC.K. (2007). Prolonged microgliosis in the rhesus monkey central nervous system after traumatic brain injury. J. Neurotrauma, 24, 1719–1742.
50.
RamlackhansinghA.F., BrooksD.J., GreenwoodR.J., BoseS.K., TurkheimerF.E., KinnunenK.M., GentlemanS., HeckemannR.A., GunanayagamK., GelosaG., and SharpD.J. (2011). Inflammation after trauma: microglial activation and traumatic brain injury. Ann. Neurol., 70, 374–383.
51.
ErdoF., DenesL., and de LangeE. (2017). Age-associated physiological and pathological changes at the blood-brain barrier: a review. J. Cereb. Blood Flow Metab., 37, 4–24.
52.
ByrnesK.R., LoaneD.J., StoicaB.A., ZhangJ., and FadenA.I. (2012). Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury. J. Neuroinflammation, 9, 43.
53.
FadenA.I. (2011). Microglial activation and traumatic brain injury. Ann. Neurol., 70, 345–346.
54.
PovlishockJ.T., ErbD.E., and AstrucJ. (1992). Axonal response to traumatic brain injury: reactive axonal change, deafferentation, and neuroplasticity. J. Neurotrauma, 9Suppl 1, S189–S200.
55.
BrownG.C. and NeherJ.J. (2010). Inflammatory neurodegeneration and mechanisms of microglial killing of neurons. Mol. Neurobiol., 41, 242–247.
56.
Bal-PriceA. and BrownG.C. (2001). Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. J. Neurosci., 21, 6480–6491.
57.
ZeccaL., GalloriniM., SchünemannV., TrautweinA.X., GerlachM., RiedererP., VezzoniP., and TampelliniD. (2001). Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes. J. Neurochem., 76, 1766–1773.
58.
VastoS., MocchegianiE., MalavoltaM., CuppariI., ListìF., NuzzoD., DittaV., CandoreG., and CarusoC. (2007). Zinc and inflammatory/immune response in aging. Ann. N. Y. Acad. Sci., 1100, 111–122.
59.
RamosP., SantosA., PintoN.R., MendesR., MagalhãesT., and AlmeidaA. (2014). Anatomical region differences and age-related changes in copper, zinc, and manganese levels in the human brain. Biol. Trace Elem. Res., 161, 190–201.
60.
AdlardP.A., ParncuttJ.M., FinkelsteinD.I., and BushA.I. (2010). Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease?. J. Neurosci., 3, 1631–1636.
61.
PortburyS.D., HareD.J., SgambelloniC.J., BishopD.P., FinkelsteinD.I., DobleP.A., and AdlardP.A. (2017). Age modulates the injury-induced metallomic profile in the brain. Metallomics. 9, 402–410.
62.
CopinschiG. and CaufriezA. (2013). Sleep and hormonal changes in aging. Endocrinol. Metab. Clin. North Am., 42, 371–389.
63.
DiekelmannS. and BornJ. (2010). The memory function of sleep. Nat. Rev. Neurosci., 11, 114–126.
64.
GenzelL., SpoormakerV., KonradB.N., and DreslerM. (2015). The role of rapid eye movement sleep for amygdala-related memory processing. Neurobiol. Learn. Mem., 122, 110–121.
65.
MotivalaS.J. (2011). Sleep and inflammation: psychoneuroimmunology in the context of cardiovascular disease. Ann. Behav. Med., 42, 141–152.
66.
ZhouD., ZhaoY., WanY., WangY., XieD., LuQ., YangS., and QiX. (2016). Neuroendocrine dysfunction and insomnia in mild traumatic brain injury patients. Neurosci. Lett., 610, 154–159.
67.
OuelletM.-C., Beaulieu-BonneauS., and MorinC.M. (2015). Sleep-wake disturbances after traumatic brain injury. Lancet Neurol. 14, 746–757.
68.
GardaniM., MorfiriE., ThomsonA., O'NeillB., and McMillanT.M. (2015). Evaluation of sleep disorders in patients with severe traumatic brain injury during rehabilitation. Arch. Phys. Med. Rehabil., 96, 1691–1697.
69.
MaselB.E., ScheibelR.S., KimbarkT., and KunaS.T. (2001). Excessive daytime sleepiness in adults with brain injuries. Arch. Phys. Med. Rehabil., 82, 1526–1532.
70.
ChavesV.E., JuniorF.M., and BertoliniG.L. (2013). The metabolic effects of growth hormone in adipose tissue. Endocrine, 44, 293–302.
71.
LangeT., DimitrovS., and BornJ. (2010). Effects of sleep and circadian rhythm on the human immune system. Ann. N. Y. Acad. Sci., 1193, 48–59.
72.
SluimerJ.D., van der FlierW.M., KarasG.B., van SchijndelR., BarnesJ., BoyesR.G., CoverK.S., OlabarriagaS.D., FoxN.C., ScheltensP., VrenkenH., and BarkhofF. (2009). Accelerating regional atrophy rates in the progression from normal aging to Alzheimer's disease. Eur. Radiol., 19, 2826–2833.
73.
JohnsonV.E., StewartW., and SmithD.H. (2012). Axonal pathology in traumatic brain injury. Exp. Neurol., 246, 35–43.
74.
BramlettH.M., KraydiehS., GreenE.J., and DietrichW.D. (1997). Temporal and regional patterns of axonal damage following traumatic brain injury: a beta-amyloid precursor protein immunocytochemical study in rats. J. Neuropathol. Exp. Neurol., 56, 1132–1141.
75.
FlemingerS., OliverD.L., LovestoneS., Rabe-HeskethS., and GioraA. (2003). Head injury as a risk factor for Alzheimer's disease: the evidence 10 years on a partial replication. J. Neurol. Neurosurg. Psychiatry, 74, 857–862.
76.
HeymanA., WilkinsonW.E., StaffordJ.A., HelmsM.J., SigmonA.H., and WeinbergT. (1984). Alzheimer's disease: a study of epidemiological aspects. Ann. Neurol., 15, 335–341.
77.
Dams-O'ConnorK., GibbonsL.E., BowenJ.D., McCurryS.M., LarsonE.B., and CraneP.K. (2013). Risk for late-life re-injury, dementia and death among individuals with traumatic brain injury: a population-based study. J. Neurol. Neurosurg. Psychiatry, 84, 177–182.
78.
LindsayJ., LaurinD., VerreaultR., HebertR., HelliwellB., HillG.B., and McDowellI. (2002). Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am. J. Epidemiol., 156, 445–453.
79.
MehtaK.M., OttA., KalmijnS., SlooterA.J., van DuijnC.M., HofmanA., and BretelerM.M. (1999). Head trauma and risk of dementia and Alzheimer's disease: the Rotterdam Study. Neurology, 53, 1959–1962.
80.
WashingtonP.M., VillapolS., and BurnsM.P. (2016). Polypathology and dementia after brain trauma: Does brain injury trigger distinct neurodegenerative diseases, or should it be classified together as traumatic encephalopathy?. Exp. Neurol., 275, 381–388.
81.
CraneP.K., GibbonsL.E., Dams-O'ConnorK., TrittschuhE., LeverenzJ.B., KeeneC.D., SonnenJ., MontineT.J., BennettD.A., LeurgansS., SchneiderJ.A., and LarsonE.B. (2017). Association of traumatic brain injury with late-life neurodegenerative conditions and neuropathologic findings. JAMA Neurol. 73, 1062–1069.
82.
TogaA.W. and ThompsonP.M. (2005). Genetics of brain structure and intelligence. Annu. Rev. Neurosci., 28, 1–23.
83.
MayeuxR., OttmanR., MaestreG., NgaiC., TangM.X., GinsbergH., ChunM., TyckoB., and ShelanskiM. (1995). Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease. Neurology, 45, 555–557.
84.
CorderE.H., SaundersA.M., StrittmatterW.J., SchmechelD.E., GaskellP.C., SmallG.W., RosesA.D., HainesJ.L., and Pericak-VanceM.A. (1993). Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science, 261, 921–923.
85.
GrahamD.I., HorsburghK., NicollJ.A., and TeasdaleG.M. (1999). Apolipoprotein E and the response of the brain to injury. Acta Neurochir. Suppl, 73, 89–92.
86.
GuoZ., CupplesL.A., KurzA., AuerbachS.H., VolicerL., ChuiH., GreenR.C., SadovnickA.D., DuaraR., DeCarliC., JohnsonK., GoR.C., GrowdonJ.H., HainesJ.L., KukullW.A., and FarrerL.A. (2000). Head injury and the risk of AD in the MIRAGE study. Neurology, 54, 1316–1323.
87.
WashingtonP.M. and BurnsM.P. (2016). The effect of the APOE4 gene on accumulation of Ab40 after brain injury cannot be reversed by increasing apoE4 protein. J. Neuropathol. Exp. Neurol., 75, 770–778.
TeasdaleG.M., MurrayG.D., and NicollJ.A. (2005). The association between APOE epsilon4, age and outcome after head injury: a prospective cohort study. Brain, 128, 2556–2561.
90.
BrodyD.L., MagnoniS., SchwetyeK.E., SpinnerM.L., EsparzaT.J., StocchettiN., ZipfelG.J., and HoltzmanD.M. (2008). Amyloid-beta dynamics correlate with neurological status in the injured human brain. Science, 321, 1221–1224.
91.
IkonomovicM.D., UryuK., AbrahamsonE.E., CiallellaJ.R., TrojanowskiJ.Q., LeeV.M., ClarkR.S., MarionD.W., WisniewskiS.R., and DeKoskyS.T. (2004). Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury. Exp. Neurol., 190, 192–203.
92.
RobertsG.W., GentlemanS.M., LynchA., and GrahamD.I. (1991). beta A4 amyloid protein deposition in brain after head trauma. Lancet, 338, 1422–1423.
93.
GuskiewiczK.M., MarshallS.W., BailesJ., McCreaM., CantuR.C., RandolphC., and JordanB.D. (2005). Association between recurrent concussion and late-life cognitive impairment in retired professional football players. Neurosurgery, 57, 719–726.
94.
BlennowK., de LeonM.J., and ZetterbergH. (2006). Alzheimer's disease. Lancet, 368, 387–403.
95.
McKeeA.C., SternR.A., NowinskiC.J., SteinT.D., AlvarezV.E., DaneshvarD.H., LeeH.S., WojtowiczS.M., HallG., BaughC.M., RileyD.O., KubilusC.A., CormierK.A., JacobsM.A., MartinB.R., AbrahamC.R., IkezuT., ReichardR.R., WolozinB.L., BudsonA.E., GoldsteinL.E., KowallN.W., and CantuR.C. (2013). The spectrum of disease in chronic traumatic encephalopathy. Brain, 136, 43–64.
PerryD.C., SturmV.E., PetersonM.J., PieperC.F., BullockT., BoeveB.F., MillerB.L., GuskiewiczK.M., BergerM.S., KramerJ.H., and Welsh-BohmerK.A. (2015). Association of traumatic brain injury with subsequent neurological and psychiatric disease: a meta-analysis. J. Neurosurg, 1–16.
99.
GoldmanS.M., TannerC.M., OakesD., BhudhikanokG.S., GuptaA., and LangstonJ.W. (2006). Head injury and Parkinson's disease risk in twins. Ann. Neurol., 60, 65–72.
100.
TaylorC.A., Saint-HilaireM.H., CupplesL.A., ThomasC.A., BurchardA.E., FeldmanR.G., and MyersR.H. (1999). Environmental, medical, and family history risk factors for Parkinson's disease: a New England-based case control study. Am. J. Med. Genet., 88, 742–749.
101.
BaldereschiM., Di CarloA., VanniP., GhettiA., CarboninP., AmaducciL., andInzitariD.; Italian Longitudinal Study on Aging Working Group. (2003). Lifestyle-related risk factors for Parkinson's disease: a population-based study. Acta Neurol. Scand., 108, 239–244.
102.
KuopioA.M., MarttilaR.J., HeleniusH., and RinneU.K. (1999). Environmental risk factors in Parkinson's disease. Mov. Disord., 14, 928–939.
103.
KraussJ.K. (2015). Movement disorders secondary to craniocerebral trauma. Handb. Clin. Neurol., 128, 475–496.
104.
LeeP.C., BordelonY., BronsteinJ., and RitzB. (2012). Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease. Neurology, 79, 2061–2066.
105.
BamfordC.R., SibleyW.A., ThiesC., LagunaJ.F., SmithM.S., and ClarkK. (1981). Trauma as an etiologic and aggravating factor in multiple sclerosis. Neurology, 31, 1229–1234.
106.
SibleyW.A., BamfordC.R., ClarkK., SmithM.S., and LagunaJ.F. (1991). A prospective study of physical trauma and multiple sclerosis. J. Neurol. Neurosurg. Psychiatry, 54, 584–589.
107.
KurlandL.T. (1994). Trauma and multiple sclerosis. Ann. Neurol., 36Suppl, S33–S37.
108.
KangJ.H. and LinH.C. (2012). Increased risk of multiple sclerosis after traumatic brain injury: a nationwide population-based study. J. Neurotrauma, 29, 90–95.
109.
WalkerA.E., LeuchsH.K., Lechtape-GruterH., CavenessW.F., and KretschmannC. (1971). The life expectancy of head injured men with and without epilepsy. Zentralbl. Neurochir., 32, 3–9.
110.
BaguleyI., Slewa-YounanS., LazarusR., and GreenA. (2000). Long-term mortality trends in patients with traumatic brain injury. Brain Inj. 14, 505–512.
111.
ShavelleR.M., StraussD., WhyteJ., DayS.M., and YuY.L. (2001). Long-term causes of death after traumatic brain injury. Am. J. Phys. Med. Rehabil., 80, 510–516.
112.
CorkinS., SullivanE.V., and CarrF.A. (1984). Prognostic factors for life expectancy after penetrating head injury. Arch. Neurol., 41, 975–977.
113.
Sela-KaufmanM., RassovskyY., AgranovE., LeviY., and VakilE. (2013). Premorbid personality characteristics and attachment style moderate the effect of injury severity on occupational outcome in traumatic brain injury: another aspect of reserve. J. Clin. Exp. Neuropsychol., 35, 584–595.
114.
CotmanC.W. and BerchtoldN.C. (2002). Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 25, 295–301.
115.
FarmerM.E., KittnerS.J., RaeD.S., BartkoJ.J., and RegierD.A. (1995). Education and change in cognitive function. The Epidemiologic Catchment Area Study. Ann Epidemiol, 5, 1–7.
116.
SilverJ.M., McAllisterT.W., and ArciniegasD.B. (2009). Depression and cognitive complaints following mild traumatic brain injury. Am. J. Psychiatry, 166, 653–661.
117.
GeurtsenG.J., van HeugtenC.M., MartinaJ.D., and GeurtsA.C.H. (2010). Comprehensive rehabilitation programmes in the chronic phase after severe brain injury: a systematic review. J. Rehabil. Med., 42, 97–110.
118.
GriesbachG.S., KreberL.A., HarringtonD., and AshleyM.J. (2015). Post-acute TBI rehabilitation: effects on outcome measures and life care costs. J. Neurotrauma, 32, 704–711.
119.
Turner-StokesL. (2008). Evidence for the effectiveness of multi-disciplinary rehabilitation following acquired brain injury: a synthesis of two systematic approaches. J. Rehabil. Med., 40, 691–701.
