The broad application of itaconic acid in synthetic resins, fibers, plastics, rubbers, surfactants, and oil additives has resulted in an increased demand for this product. As an end step of biobased itaconic acid production, a suitable downstream recovery procedure using Aspergillus terreus as a study model was analyzed. Here we present preliminary work to integrate fungal fermentation with in-stream product recovery (ISPR) using pertraction for itaconic acid. Based on prior knowledge and an initial solvent screening, solvent extraction using 2-methyl tetrahydrofuran (2m-THF) was selected as the preferred technique for recovering itaconic acid.1,2
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