Organ-Chips and Omics Advance Cancer Research

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References

Roy Castle Lung Cancer Foundation. Jackie Spotted the Difference. November 1, 2021. Available at: https://roycastle.org/jackie-spotted-the-difference/ (accessed January 2022).

US National Cancer Institute. Cancer Stat Facts: Lung and Bronchus Cancer. Available at: https://seer.cancer.gov/statfacts/html/lungb.html (accessed January 2022).

Cancer Grand Challenges. STORMing Cancer. Cancer Research UK. Available at: https://cancergrandchallenges.org/teams/storming-cancer (accessed November 2021).

Alvarez

. $26 Million ‘Grand Challenge’ Project Will Probe Role of Inflammation in Cancer. UCSF News. Jan 23, 2019. Available at: https://www.ucsf.edu/news/2019/01/413116/26-million-grand-challenge-project-will-probe-role-inflammation-cancer (accessed November 2021).

Lowe

, Kudaravalli

, Hsu

. Barrett Metaplasia. Updated, 2021 July 26. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2021 January. Available at: https://www.ncbi.nlm.nih.gov/books/NBK459330/ (accessed November 2021).

Hudson

. Memories of Cancer: What the Extra-cellular Matrix Can Tell Us about Cancer and How to Combat It. Technology Networks . September 15, 2021. Available at: https://www.technologynetworks.com/cancer-research/articles/memories-of-cancer-what-the-extracellular-matrix-can-tell-us-about-cancer-andhow-to-combat-it-353689 (accessed November 2021).

Maoz

, Herland

, FitzGerald

, et al. A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells. Nat. Biotechnol . 2018; 36(9): 865–874.

Herland

, Maoz

, FitzGerald

, et al. Proteomic and Metabolomic Characterization of Human Neurovascular Unit Cells in Response to Methamphetamine. Adv. Biosyst. , 2020; 4(9): e1900230.

Benam

, Novak

, Nawroth

, et al. Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip. Cell Syst. , 2016; 3(5): 456–466.e4.

10.

Tovaglieri

, Sontheimer-Phelps

, Geirnaert

, et al. Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. Microbiome , 2019; 7(1): 43.

11.

, Bai

, Oh

, et al. Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity. bioRxiv , 2021 November 22. DOI: 10.1101/2021.11.19.469183.

12.

, Bai

, Oh

, et al. Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-Chip. Microbiol. Spectr. , 2021; 9(2): e0025721.

13.

Bai

, Si

, Jiang

, et al. Mechanical control of innate immune responses against viral infection revealed in a human Lung Alveolus Chip. bioRxiv , 2021 April 27. DOI: https://doi.org/10.1101/2021.04.26.441498.

14.

Emulate. About Emulate. Leadership. Donald Ingber. Available at: https://emulatebio.com/about/ (accessed November 2021).

15.

Emulate. Products & Services. Available at: https://emulatebio.com/products-services/ (accessed January 2022).

16.

Collins

. NIH Director's Blog. Making Personalized Blood-Brain Barriers in a Dish. Jun 27, 2019. Available at: https://directorsblog.nih.gov/2019/06/27/making-personalized-blood-brain-barriers-in-a-dish/ (accessed November 2021).

17.

Low

, Mummery

, Berridge

, et al. Organs-on-chips: Into the next decade. Nat. Rev. Drug Discov . 2021; 20: 345–361.

18.

Workman

, Gleeson

, Troisi

, et al. Enhanced Utilization of Induced Pluripotent Stem Cell–Derived Human Intestinal Organoids Using Microengineered Chips. Cell. Mol. Gastroenterol. Hepatol. , 2018; 5(4): 669–677.e2.

19.

Junaid

, Schoeman

, Yang

, et al. Metabolic response of blood vessels to TNF?. eLife , 2020; 9: e54754.

20.

Congress.gov. H.R.2565—FDA Modernization Act of 2021. April 15, 2021. Available at: https://www.congress.gov/bill/117th-congress/house-bill/2565/text?q=%7B%22search%22%3A%5B%22H.R.+1%22%5D%7D&r=33&s=1#:~:text=Introduced%20in%20House%20(04%2F15%2F2021)&text=To%20amend%20the%20Federal%20Food,drug%2C%20and%20for%20other%20purposes (accessed November 2021).

21.

Emulate. Emulate Endorses the FDA Modernization Act of 2021. October 7, 2021. Available at: https://emulatebio.com/fda-modernizationact/?utm_content=183536003&utm_medium=social&utm_source=twitter&hss_channel=tw-2670800390 (accessed November 2021).