Welcome Alternatives to Animal Testing

https://www.congress.gov/bill/117th-congress/senate-bill/2952.

Lemere CA . Developing novel immunogens for a safe and effective Alzheimer's disease vaccine. Prog. Brain Res. , 2009; 175: 83–93.

Allen A . Of Mice or Men: The Problems with Animal Testing. Slate . https://slate.com/technology/2006/06/does-animal-testing-work.html. Published June 1, 2006.

Attarwala H . TGN1412: From Discovery to Disaster. J. Young Pharm. , 2010; 2(3): 332–336.

Eglovitch JS . Animal models have limitations for safety assessment of gene therapies: FDA adcomm. Regulatory Affairs Professionals Society. https://www.raps.org/news-and-articles/news-articles/2021/9/fda-adcomm-points-to-limitations-of-animal-studies. Published September 2, 2021.

George LA . Systemic AAV: Clinical Findings of Hepatotoxicty. Presentation at: CTGTAC: Toxicity Risks of AAV Vectors for Gene Therapy. September 2–3, 2021. https://www.fda.gov/media/151964/download.

Schneider LS , Mangialasche F , Andreasen N , et al. Clinical trials and late-stage drug development in Alzheimer's disease: An appraisal from 1984 to 2014. J. Int. Med . 2014; 275: 251–283.

Seok J , Warren HS , Cuenca AG , et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc. Natl. Acad. Sci. USA , 2013; 110: 3507–3512.

O'Collins VE , Macleod MR , Donnan GA , et al. 1,026 experimental treatments in acute stroke. Ann. Neurol. , 2006; 59(3): 467–477.

Bailey J . Letter. Altern. Lab. Anim . 2017; 45(4): 213–218.

Taylor NP . J&J's HIV vaccine fails phase 2b, extending long wait for an effective jab. Fierce Biotech . https://www.fiercebiotech.com/biotech/j-j-s-hiv-vaccine-fails-phase-2b-extending-long-wait-for-effective-jab. Published August 31, 2021.

Taylor NP . J&J gears up for clinical test of HIV vaccine efficacy. Fierce Biotech. . https://www.fiercebiotech.com/biotech/j-j-gears-up-for-clinical-test-hiv-vaccine-efficacy. Published July 15, 2019.

Greek R , Greek J . Animal research and human disease. JAMA , 2000; 283: 743–744.

Tagle DA . The NIH microphysiological systems program: developing in vitro tools for safety and efficacy in drug development. Curr. Opin. Pharmacol. , 2019; 48: 146–154.

Gardner J . New estimate puts cost to develop a new drug at $1B, adding to long-running debate. Biopharma Dive . https://www.biopharmadive.com/news/new-drug-cost-research-development-market-jama-study/573381/. Published March 3, 2020.

Brownell L . Harvard's Wyss Institute Receives Funding Award from BARDA. Wyss Institute. https://wyss.harvard.edu/news/harvards-wyss-institute-receives-funding-award-from-barda/. Published September 24, 2021.

Walrath R . Draper inks $719K BARDA contract to develop lung chip for Covid-19 research. Boston Business Journal . https://www.bizjournals.com/boston/news/2021/09/23/draper-lab-organ-lung-chip-hhs-barda-covid-19.html. Published September 23, 2021.

Marx U , Andersson TB , Bahinski A , et al. Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing. Altern. Anim. Exp . 2016; 33(3): 272–321.