Microbiome May Join Immunotherapy-Boosting Efforts

Thompson J , Szabo A , Arce-Lara C , and Menon S . Microbiome & immunotherapy: Antibiotic use is associated with inferior survival for lung cancer patients receiving PD-1 inhibitors. J. Thorac. Oncol. , 2017; 12(11): S1998.

Derosa L , Routy B , Enot D , et al. Impact of antibiotics on outcome in patients with metastatic renal cell carcinoma treated with immune checkpoint inhibitors. J. Clin. Oncol. , 2017; 35(Suppl. 6): 462.

Elkrief A , El Raichani L , Richard C , et al. Antibiotics are associated with decreased progression-free survival of advanced melanoma patients treated with immune checkpoint inhibitors. Oncoimmunology , 2019; 8(4): e1568812.

Matson V , Fessler J , Bao R , et al. The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients. Science , 2018; 359(6371): 104–108.

Pushalkar S , Hundeyin M , Daley D , et al. The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression. Cancer Discov. , 2018; 8(4): 403–416.

Riquelme E , Zhang Y , Zhang L , et al. Tumor microbiome diversity and composition influence pancreatic cancer outcomes. Cell , 2019; 178(4): 795–806.e12.

Geller LT , Barzily-Rokni M , Danino T , et al. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science , 2017; 357(6356): 1156–1160.

Henriksen A , et al. Checkpoint inhibitors in pancreatic cancer. Cancer Treat. Rev . 2019; 78: 17–30.

ClinicalTrials.gov . Melanoma checkpoint and gut Microbiome alteration with microbiome intervention (MCGRAW). www.clinicaltrials.gov/ct2/show/NCT03817125. Accessed February 28, 2020.

ClinicalTrials.gov . A study of EDP1503 in patients with colorectal cancer, breast cancer, and checkpoint inhibitor relapsed tumors. www.clinicaltrials.gov/ct2/show/ NCT03775850. Accessed February 28, 2020.

ClinicalTrials.gov . Fecal microbiota transplant (FMT) in melanoma patients. https://clinicaltrials.gov/ct2/show/NCT03341143. Accessed February 28, 2020.

ClinicalTrials.gov . Fecal microbiota transplantation (FMT) in metastatic melanoma patients who failed immuno-therapy. https://clinicaltrials.gov/ct2/show/NCT03353402. Accessed February 28, 2020.

DeFilipp Z , Bloom PP , Torres Soto M , et al. Drug-resistant E. coli bacteremia transmitted by fecal microbiota transplant. N. Engl. J. Med . 2019; 381(21): 2043–2050.

Haslam A , Prasad V . Estimation of the percentage of US patients with cancer who are eligible for and respond to checkpoint inhibitor immunotherapy drugs. JAMA Netw. Open , 2019; 2(5): e192535.