Single-Cell Explorations Are Underway,and Spatial Is the Next Frontier

Pennisi E . Development cell by cell. Science , 2018; 362(6421): 1344–1345.

Human Cell Atlas. www.humancellatlas.org

Tabula Muris Consortium. Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. Nature , 2018; 562(7727): 367–372.

Montoro DT et al. A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. Nature , 2018; 560(7718): 319–324.

Peng YR et al. Molecular Classification and Comparative Taxonomics of Foveal and Peripheral Cells in Primate Retina. Cell , 2019; 176(5): 1222–1237.

Mathys H et al. Single-cell transcriptomic analysis of Alzheimer's disease. Nature 2019 (May 1): doi: 10.1038/s41586-019-1195-2. [Epub ahead of print]

Vladoiu MC et al. Childhood cerebellar tumours mirror conserved fetal transcriptional programs. Nature , 2019 (May 1): doi: 10.1038/s41586-019-1158-7. [Epub ahead of print]

Zhang P et al. Dissecting the Single-Cell Transcriptome Network Underlying Gastric Premalignant Lesions and Early Gastric Cancer. Cell Reports , 2019; 27(6): 1934–1947.

MacParland SA et al. Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations. Nature Communications , 2018; 9(1): 4383.

Paulson KG et al. Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA. Nature Communications , 2018; 9(1): 3868.

Azizi E et al. Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment. Cell , 2018; 174(5): 1293–1308.

Tikhonova AN et al. The bone marrow microenvironment at single-cell resolution. Nature , 2019; 569(7755): 222–228.

Nawy T . Spatial Transcriptomics [Method to Watch]. Nature Methods , 2018; 15: 30.

Ståhl PL et al. Visualization and analysis of gene expression in tissue sections by spatial transcriptomics. Science , 2016; 353(6294): 78–82.