We have recently proposed a mathematical framework for crowd-sourcing of biomedical image analysis and diagnosis through digital gaming. Here we review our recent progress on this gaming platform and demonstrate its viability for telediagnosis of malaria, achieving an accuracy that is within less than 2 percent of that of a trained expert.
Get full access to this article
View all access options for this article.
References
1.
TsengD, MudanyaliO, OztoprakCet al.Lensfree microscopy on a cellphone. Lab Chip, 2010; 10:1787–1792.
2.
BisharaW, SuTW, CoskunAF, OzcanA. Lens- free on-chip microscopy over a wide field-of-view using pixel super-resolution. Optics Express, 2010; 18:11181–11191.
ZhuH, MavandadiS, CoskunAFet al.Optofluidic fluorescent imaging cytometry on a cell phone. Anal Chem, 2011; 83:6641–6647.
5.
IsikmanSO, BisharaW, MavandadiSet al.Lensfree optical tomographic microscope with a large imaging volume on a chip. Proc Natl Acad Sci U S A, 2011; 108:7296–7301.
6.
ZhuH, SikoraU, OzcanA. Quantum dot enabled detection of Escherichia coli using a cell-phone. Analyst, 2012; 137:2541–2544.
7.
GreenbaumA, SikoraU, OzcanA. Field-portable wide-field microscopy of dense samples using multi-height pixel super-resolution based lensfree imaging. Lab Chip, 2012; 12:1242–1245.
8.
GaltonF. Vox Populi [reprint from 1907]Nature, 1949; 75:450–451.
9.
von AhnL, MaurerB, McMillenCet al.reCAPTCHA: Human-based character recognition via Web security measures. Science, 2008; 321:1465–1468.
10.
CooperS, KhatibF, TreuilleAet al.Predicting protein structures with a multiplayer online game. Nature, 2010; 466:756–760.
11.
KhatibF, CooperS, TykaMDet al.Algorithm discovery by protein folding game players. Proc Natl Acad Sci U S A, 2011; 108:18949–18953.
MavandadiS, DimitrovS, FengSet al.A. Distributed medical image analysis and diagnosis through crowd-sourced games: A malaria case study. PLoS One, 2012; 7:e37245.
14.
MavandadiS, DimitrovS, FengSet al.Crowd-sourced BioGames: Managing the big data problem for next-generation lab-on-a-chip platforms. Lab Chip, 2012Aug23[Epub ahead of print]10.1039/C2LC40614D.
15.
World Health Organization. World Malaria Report 2011. Geneva: World Health Organization, 2011.
16.
AmexoM, TolhurstR, BarnishG, BatesI. Malaria misdiagnosis: Effects on the poor and vulnerable. Lancet, 2004; 364:1896–1898.