Cumulative Impacts: Scientific Drivers and Approaches from Exposomics and Sustainability

Abstract

The Environmental Protection Agency’s Interim Framework for Advancing Consideration of Cumulative Impacts was issued as a foundation for implementing approaches to address the cumulative burden of environmental exposures and health disparities that impact many communities. This commentary describes disparities in environmental exposures and health and identifies biomarkers of and potential mechanisms underlying vulnerability and health disparities. It also observes the parallel approaches utilized in the fields of exposomics, One Health, and sustainability to prioritize and characterize exposure and health disparities in ways that can identify actions to mitigate adverse exposures and yield healthier and more sustainable communities.