Abstract
Purpose:
To investigate oncological outcomes in patients with muscle-invasive bladder cancer who underwent open radical cystectomy (ORC), laparoscopic radical cystectomy (LRC), or robot-assisted radical cystectomy (RARC).
Patients and Methods:
A retrospective analysis was performed on 230 patients who underwent ORC (n = 150), LRC (n = 22), or RARC (n = 58) between September 2009 and June 2012. Perioperative outcomes were compared between the three surgical approaches. The influence of the type of surgical approach on recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS) was analyzed using the Kaplan–Meier method, and differences were assessed with the log-rank test. Predictors of RFS, CSS, and OS were also analyzed with a Cox regression model.
Results:
The median patient age for ORC, LRC, and RARC groups was 68.0 (interquartile range [IQR]: 60.0–73.0), 65.0 (IQR: 62.8–74.0), and 61.5 (IQR: 54.8–72.0) years, respectively (p = 0.017), and the median follow-up duration was 27.9 (IQR: 14.7–47.9), 28.8 (IQR: 15.7–41.8), and 32.0 (IQR: 15.5–45.4) months, respectively (p = 0.955). There was no significant difference in RFS, CSS, and OS according to the surgical approach (p = 0.253, p = 0.431, and p = 0.527, respectively). Subgroup analysis revealed that RFS, CSS, and OS were not significantly different in both subgroups with stage ≤pT2 or ≥pT3. Multivariable Cox regression analyses showed that the surgical approach was not a significant predictor of RFS, CSS, and OS.
Conclusion:
Our findings indicate that the type of surgical approach is not associated with RFS, CSS, and OS in patients with bladder cancer.
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